Fourth Hospital of Hebei Medical University

XGBoost–SHAP-based interpretable predictive website for postoperative in-hospital mortality in patients with acute aortic dissection

Developing a convenient and accurate prognostic model for patients with acute aortic dissection (AAD) using routine demographic and clinical data is challenging. This study aimed to develop an interpretable web-based prediction model using extreme gradient boosting with Shapley a...

Fluoroscopic Catheter-Tip Positioning During Internal Jugular TIVAD Placement in Breast Cancer: A Two-Center Retrospective Cohort Study

Background/Objectives: Fluoroscopy permits direct assessment of catheter course and tip position during totally implantable venous access device (TIVAD) placement. We compared left- and right-sided internal jugular vein (IJV) port placement in breast cancer. Methods: This retrosp...

Dual-docking robotic total proctocolectomy for familial adenomatous polyposis with synchronous rectal and sigmoid carcinomas: a methodology of port placement and docking strategy

Abstract Dual-docking robotic total proctocolectomy (TPC) for familial adenomatous polyposis (FAP) with synchronous carcinomas presents technical challenges in port placement, and a detailed methodology is currently lacking. This article reports a case of dual-docking robotic TPC...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Glioblastoma mimicking a cerebral cavernous malformation: case report

Glioblastoma is the most common malignant tumor of the central nervous system, and its diagnosis is typically straightforward based on clinical and neuroimaging data. However, when glioblastoma and cavernous hemangioma exhibit overlapping MRI features, the diagnosis becomes chall...

Diagnostic performance of combined ultrasound parameters, B-hCG, and estradiol in early caesarean scar pregnancy and their association with intraoperative bleeding during curettage

Cesarean scar pregnancy (CSP), a serious complication following cesarean section, may increase the risk of massive intraoperative bleeding and hysterectomy due to the implantation of the gestational sac at the uterine scar site. This study employed a prospective cohort analysis t...

Diagnostic accuracy and prognostic value of lncRNA H19 in gastric cancer: a systematic review and meta-analysis

Abstract Background LncRNA H19 is upregulated considerably in gastric cancer and participates in its apoptosis, proliferation, migration, invasion, and metastasis. The objective of this meta-analysis is to demonstrate its diagnostic and prognostic values for gastric cancer. Metho...

Exosomes From Cancer‐Associated Fibroblasts Suppress Ferroptosis and CD8 + T Cell Effector Function in Gastric Cancer via miR ‐4435/ NDUFA10 Axis

ABSTRACT Cancer‐associated fibroblasts (CAFs) are pivotal stromal component in tumor microenvironment (TME) and participate in regulating tumor development and progression via exosomes (exos) mediated intercommunication. However, the intricate mechanism underlying the exosomal mi...

Long-term outcomes and prognostic factors in patients aged 70 years or older with early esophageal squamous cell carcinoma undergoing endoscopic submucosal dissection

Given the aging population, we aimed to evaluate the long-term outcomes and prognostic factors of overall survival (OS) in elderly patients who underwent endoscopic submucosal dissection (ESD) for early esophageal squamous cell carcinoma (ESCC). Between January 2000 and June 2022...

Targeting Tc17 cell differentiation via the IL-6/JAK1/STAT3 signaling axis to attenuate immune checkpoint inhibitor-related colitis and promote tumor immunity

Immune checkpoint inhibitor-related colitis (IRC) is one of the most common immune-related adverse events, yet its underlying mechanisms remain unclear and treatments lack precision targeting. This study aims to elucidate the immune cell infiltration characteristics and regulator...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

The FOXQ1/SSBP2 Regulatory Axis Drives Malignant Progression of Melanoma

ABSTRACT Melanoma is a highly aggressive skin cancer with poor prognosis, often linked to excessive UV exposure. Despite advancements in immunotherapy and targeted treatments, melanoma's invasiveness and metastatic potential remain significant challenges. This study aimed to iden...

Prognostic value of CD8+ TILs and MMR status and their correlation with clinical outcomes in rectal cancer

Abstract Objective To explore the relationship between CD8 + tumor-infiltrating lymphocytes (TILs) in rectal cancer, mismatch repair (MMR) status, and patient prognosis. Methods A total of 414 paraffin-embedded tissue samples from patients with pathologically confirmed stage Ⅰ–Ⅲ...

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Pre-treatment serum bicarbonate predicts survival in patients with locally advanced esophageal squamous cell carcinoma undergoing definitive radiotherapy: a retrospective propensity score matching study

This study aimed to evaluate the prognostic value of pre-treatment serum bicarbonate (HCO 3 − ) for overall survival (OS) and progression-free survival (PFS) in locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients undergoing definitive radiotherapy. Patients wit...

Association between A Body Shape Index (ABSI) and lung cancer risk among never-smoking women in Northern China: a population-based prospective cohort study

Abdominal obesity, particularly visceral fat accumulation, increases the risk of lung cancer. As a novel anthropometric metric, A Body Shape Index (ABSI) offers improved quantification of abdominal obesity. This study aimed to investigate the association between ABSI and lung can...

Expression, association with clinicopathological features and prognostic potential of FOXR2, mTOR, HIF−1α and PKM2 in high−grade serous carcinoma of the ovary

High−grade serous carcinoma (HGSC) of the ovary is the most common and deadly subtype of gynecological malignancy. More and more studies have shown that Forkhead Box R2 (FOXR2) is a carcinogenic driver that can enhance cell growth and tumor formation. However, the role of FOXR2 i...

DMS-Vmunet: dynamic multi-scale vision Mamba Unet for non-small cell lung cancer CT image segmentation

Abstract The CT image segmentation task of non-small cell lung cancer (NSCLC) suffers from the challenges of small target and severe background noise interference, etc. Current research incorporates a variety of neural network architectures to improve the overall segmentation per...

LINC01446/miR-338-3p/APEX1 Axis Promotes Ferroptosis Defense and Progression in Esophageal Squamous Cell Carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a poor prognosis, highlighting the urgent need to elucidate its molecular mechanisms to develop targeted therapies. Long non-coding RNAs (lncRNAs) play a critical role in cancer progression. Ho...