Fourth Affiliated Hospital of Harbin Medical University

Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome

Onco-fetal reprogramming of the tumor ecosystem induces fetal-like characteristics, leading to tumor growth and malignant progression. Here, we develop a robust computational pipeline to systematically identify onco-fetal (OF) cells, using single-cell transcriptomic data from cor...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

A New Perspective on the Regulation of Microglia-Mediated Inflammation in Diabetic Retinopathy: Mechanisms of NLRP3 Inflammasome Activation and Therapeutic Strategies

Diabetic retinopathy (DR) is among the most common complications of diabetes mellitus and is characterized by microangiopathy and neurodegeneration. Microglia constitute a resident immune population in the central nervous system (CNS) and play crucial roles in regulating retinal...

Thrombus-Targeted and Reactive Oxygen Species-Responsive Apigenin Liposomes for Ischemic Stroke

Abstract Ischemic stroke remains a leading cause of mortality and long-term disability, while current therapies inadequately address oxidative stress, mitochondrial dysfunction, and blood–brain barrier (BBB) disruption during ischemia and reperfusion. Here, we developed DPCT@LIP-...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...

Crystal structure of 9-(4-bromophenyl)-3,4,6,7,9,10-hexahydroacridine-1,8(2 H ,5 H )-dione, C 19 H 18 BrNO 2

Abstract C 19 H 18 BrNO 2 , monoclinic, P 2 1 / n (no. 14), a = 8.911(2) Å, b = 10.862(3) Å, c = 16.883(4) Å, β = 98.547(5)°, V = 1616.1(7) Å 3 , Z = 4, R gt ( F ) = 0.0449, wR ref ( F 2 ) = 0.1562, T = 296(2) K.