Fourth Affiliated Hospital of China Medical University

Benchmarking of pathology foundation models for assessing HER2 amplification and CEP17 polysomy in breast cancer

Abstract Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) amplification and Chromosome 17 (CEP17) copy number is critical for breast cancer treatment, yet diagnostically equivocal (IHC 2+) cases remain a clinical bottleneck. This study systematically benchma...

Efficacy and evidence certainty of traditional Chinese exercises for musculoskeletal disorders: an umbrella review of meta-analyses

Objectives To comprehensively evaluate the efficacy and exercise prescription parameters of traditional Chinese exercises (TCEs) on health outcomes in patients with musculoskeletal disorders (MSDs) and rigorously assess the certainty of the evidence. Design Umbrella review. Data...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies

The tumor microenvironment (TME) exhibits widespread immunophenotypic heterogeneity. Based on the spatial immune contexture, tumor immune profiles can be classified as immune-inflamed, excluded, or desert. Immune-excluded tumors, a distinct tumor immune phenotype, are characteriz...

Interim Efficacy Analysis of Different Anticoagulation Regimens in Patients with Long-term Implantation of Inferior Vena Cava Filter

Abstract: To analyze the interim efficacy of different anticoagulation regimens for patients with long-term inferior vena cava filter (IVCF) implantation. From August 2021 to August 2024, a retrospective analysis of patients who underwent long-term IVCF implantation in multiple c...