Foshan Maternity and Child Health Care Hospital

Causal association between plasma vascular endothelial growth factor family proteins and placenta previa

This study investigates associations between genetically proxied plasma vascular endothelial growth factor (VEGF) family proteins and placenta previa using 2-sample Mendelian randomization (MR). Exposure GWAS summary statistics were obtained from the UK Biobank and IEU resources,...

Biomarker-Guided Diagnosis of Riboflavin Transporter Deficiency Presenting as Seronegative Myasthenia Gravis: A Short Report from a Consanguineous Family

Background: Brown–Vialetto–Van Laere syndrome (BVVLS) is a rare, treatable neurodegenerative disorder caused by riboflavin transporter gene variants (SLC52A2, SLC52A3). Early symptoms can mimic neuromuscular junction disorders, causing diagnostic delays. Case Presentation: A 3.5-...

Single-cell transcriptomics combined with Mendelian randomization reveals the pivotal role of WDR83OS in clear cell renal cell carcinoma

This study aimed to comprehensively investigate the molecular mechanisms of clear cell renal cell carcinoma (ccRCC), identify key cellular subpopulations and genes, develop an effective diagnostic model, and screen potential targeted therapies for ccRCC. We analyzed single-cell t...

The imperative of newborn screening programs in developing countries: beyond the illusion of health at birth

Newborn screening (NBS) represents one of the most significant achievements in preventive public health, enabling early detection of congenital disorders before symptom onset. While developed nations have established comprehensive NBS programs covering 30–50 conditions, many low-...

High-proportion of human milkfeeding reduces necrotizing enterocolitis and feeding intolerance among very preterm infants

Abstract Background Very preterm infants (VPIs; gestational age 28–31⁺⁶ weeks) are highly susceptible to necrotizing enterocolitis (NEC) and feeding intolerance (FI) because of their gastrointestinal immaturity. Although breast milk contains protective bioactive components, the o...

Altered circulating blood microbiota in unexplained recurrent spontaneous abortion

The etiology of unexplained recurrent spontaneous abortion (URSA) remains poorly understood. Emerging evidence implies that URSA is closely related to dysbiosis of the symbiotic microbiota, while the characteristics of blood microbiome in URSA remain unclear. In the present preli...

Unraveling the hormonal causality in postpartum depression: findings from a two-sample Mendelian randomization study

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...