Food for Health Ireland

Single-nucleus transcriptomic analysis reveals subfield-specific cell-to-cell synaptic reorganisation of the mouse hippocampus in focal temporal lobe epilepsy

Preclinical animal models are critical tools to study the pathophysiology of epilepsy. The intra-amygdala microinjection of kainic acid in mice recapitulates key features of drug-resistant temporal lobe epilepsy, including unilateral hippocampal pathology and broad resistance to...

Macrophages tune NK cell IFNγ production through direct lipid transfer

Abstract Natural killer (NK) cells are critical effectors of innate immunity, but their activity is strongly influenced by metabolic state. While intrinsic NK metabolism has been studied extensively, less is known about how surrounding immune cells shape NK cell function. Here, w...