Fondazione Toscana Gabriele Monasterio

Long‐Term Progression to Permanent Atrial Fibrillation After Cryoballoon Pulmonary Vein Isolation: Insights From the Multicenter 1STOP Project

ABSTRACT Background Atrial fibrillation (AF) often progresses from paroxysmal to persistent forms, culminating in permanent AF, a transition associated with increased risks of stroke, heart failure, and hospitalization. Cryoballoon pulmonary vein isolation (CB‐PVI) is an establis...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

Pancreatic iron overload as a marker of endocrine complications in transfusion‐dependent thalassaemia: A multicentre study

This multicentre cross-sectional study evaluated whether pancreatic iron loading could serve as a reliable biomarker for the identification of endocrine disorders in transfusion-dependent thalassaemia (TDT) patients. A total of 994 adult TDT patients (53.7% female; 39.2 ± 8.3 yea...

Age-Related Patterns of Organ-Specific Iron Distribution in Non-Transfusion-Dependent Thalassemia: A Multicenter MRI Study

Objectives: This multicenter cross-sectional study investigated the relationship between age and organ-specific iron burden and characterized multi-organ iron phenotypes across different age groups in adults with non-transfusion-dependent thalassemia (NTDT). Methods: We retrospec...

Sex Differences in a Contemporary, Real-World Cohort of Patients with Transthyretin Amyloid Cardiomyopathy Treated with Tafamidis

INTRODUCTION: Tafamidis improves outcomes in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) versus placebo. ATTR-CM has historically been considered a predominantly male disease, and women are underrepresented in prior studies. Sex-specific data in contemporary pati...

Development and Internal Validation of a Clinical Risk Score for Hypovitaminosis D in Italian Adults Aged ≥50 Years Attending Osteoporosis and Metabolic Bone Disease Centers

Background/Objectives: Hypovitaminosis-D is a highly prevalent condition worldwide, associated with adverse skeletal and extra-skeletal outcomes. Increasing demand for serum 25-hydroxyvitamin D (25(OH)D) testing points toward the need for simple tools to identify individuals at r...

The New Cardio-Oncology Frontier in Hematologic Cancers: Cardiovascular Toxicities of CAR-T Cells and Bispecific T-Cell Engagers

Chimeric antigen receptor T-cell therapy and bispecific T-cell engagers have transformed treatment of relapsed and refractory hematologic malignancies, achieving unprecedented response rates. However, their clinical adoption has revealed a complex spectrum of cardiovascular toxic...

Florbetaben PET for early and non-invasive diagnosis of light chain amyloidosis: a case report and brief review of the literature

Light chain amyloidosis is a hematological disease requiring rapid diagnosis and urgent therapeutic intervention. The confirmation of the clinical suspicion demands invasive methods, in order to demonstrate histological involvement of organs. Substantial efforts are required espe...