Institution
Fondazione Santa Lucia
Recent research
- Health & MedicineOpen access
Abstract Atypical B-cells (ABCs) are observed across infections, yet their ontogeny and differentiation remain unclear. Using high-dimensional flow cytometry, single-cell transcriptomics, V(D)J sequencing, and functional assays in samples from individuals with malaria and healthy...
- BiologyOpen access
Abstract The cerebellum is a key node for detecting and adjusting social-prediction internal models. Yet social prediction has been scantly investigated in neurodegenerative cerebellar patients (CB). Thus, we examined CB social-prediction abilities and related cerebellar-cerebral...
- Health & MedicineOpen access
Acidic cannabinoids, including tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), and related biosynthetic precursors, represent the predominant phytocannabinoid forms naturally produced by Cannabis sativa . Long considered pharmacologicall...
- Society & EconomicsOpen access
Abstract Background Sleep disturbances are common after stroke and have been associated with rehabilitation outcomes. The clinical meaning of post-stroke sleep duration remains unclear, as longer sleep may be associated with different clinical and functional states, including gre...
- BiologyOpen access
Background: Tinnitus is a heterogeneous percept that becomes a disorder when it is accompanied by clinically meaningful distress or functional impairment. Hearing loss is a major contributor, while temporomandibular, cervical, sleep, psychological, and contextual factors can shap...
- BiologyOpen access
High-fat diet promotes T cell–mediated synaptic dysfunction in multiple sclerosis
Early glutamatergic synaptopathy contributes to disease progression in multiple sclerosis (MS), leading to excitotoxic synaptic damage. Although high-fat diet (HFD)–associated peripheral inflammation has been linked to central nervous system dysfunction, how metabolic and immune...
- Health & MedicineOpen access
Angiogenesis is a major determinant of tumor growth, progression and metastatic potential, and its persistent activation is closely intertwined with chronic inflammation. This relationship is particularly relevant in malignancies that arise through a prolonged inflammation-to-car...
- Materials & EnergyOpen access
Abstract The aim of this work is to evaluate different nanostructured systems based on noble metal nanoparticles suitable for drug delivery and release related to the treatment of multiple sclerosis. To this end, four different systems are thoroughly characterized from a chemical...
- Health & MedicineOpen access
ABSTRACT Functional dyspepsia (FD) is a common disorder of gut‐brain interaction in which gastric sensorimotor abnormalities may coexist with impaired duodenal barrier function, low‐grade immune activation, and altered neuroimmune signaling. Peroxisome proliferator‐activated rece...
- Health & MedicineOpen access
Alterations in interoception have been implicated in several neurological and psychiatric conditions, including those involving dissociative tendencies. Thus, investigating the link between interoception and dissociation may shed light on the mechanisms supporting self-consciousn...
- Health & Medicine
Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice
Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...
- BiologyOpen access
Abstract Acute promyelocytic leukemia (APL) is curable with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), but differentiation syndrome (DS) remains a potentially life-threatening complication, with poorly understood pathogenesis. We investigated clinical, molecular a...
- Health & MedicineOpen access
Background/Objectives: Hypovitaminosis-D is a highly prevalent condition worldwide, associated with adverse skeletal and extra-skeletal outcomes. Increasing demand for serum 25-hydroxyvitamin D (25(OH)D) testing points toward the need for simple tools to identify individuals at r...
- Health & MedicineOpen access
The Mind From Within: Visceral Roots of Human Cognition
ABSTRACT Humans think and act not only with the brain but also with the heart, lungs, gut, and other viscera, such as the bladder, long regarded as primarily vegetative. A fresh wave of experiments is revealing the role of cardiac‐cycle phase and baroreceptor firing in perception...
- BiologyOpen access
Unveiling the Neural Correlates of Incidental Memory: a Meta-analysis of fMRI Studies
A significant body of research sought to understand the mechanisms underlying memory formation and retrieval. Even when focusing exclusively on episodic memory, several subcategories emerge, such as explicit, implicit, and autobiographical memory. In this study, we utilized Activ...
- BiologyOpen access
Colitis-associated colorectal cancer (CAC) arises from the interplay between chronic inflammation, epithelial dysregulation, angiogenesis, and microbiota alterations. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-angiogenic properties...
- BiologyOpen access
Previous studies have investigated the effects of Dante’s poetry on emotional arousal and cognitive workload in healthy participants by comparing excerpts from the Inferno and Paradiso of the Divina Commedia. In this pilot study, conducted in a hospital setting, we measured elect...