Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

A consortium-driven framework for biomarker prioritization in the HEBE aging study

Abstract Aging is a complex biological process influenced by chronic low-grade inflammation, oxidative stress, and metabolic dysregulation, collectively termed inflammaging. The HEBE (Healthy aging versus inflamm-aging: the role of physical Exercise in modulating the Biomarkers o...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Explantation rates and failure mechanisms in early cannulation grafts: A comparative study between Flixene and Gore Acuseal

Background: Early cannulation arteriovenous grafts (ecAVGs) are increasingly used to reduce catheter dependence in hemodialysis patients, but device-specific complications remain a concern. This study aimed to compare explantation rates, timing, and mechanisms of failure between...

Epithelioid infraligamentary uterine leiomyoma in an adolescent: imaging–pathology correlation and minimally invasive management

Abstract Background Epithelioid uterine leiomyoma is an uncommon histological variant and is exceptionally rare in adolescence. Its unusual anatomical presentation may complicate preoperative characterization, while definitive diagnosis relies on histopathological evaluation, inc...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

I casi studio per testare utilità e validità dell'Atlante Aria Salute: definizione del quadro concettuale.

OBJECTIVES: to describe the process of selecting and applying a shared conceptual model for the analysis of case studies designed to test the usefulness and validity of the Air and Health Atlas in supporting decision-making, in its current version and in its potential future deve...

Stress reduces loss aversion without increasing reward-cue attentional salience

Abstract Attentional and evaluative decision biases both shape motivated behavior, yet their interplay under acute stress remains unclear. We tested whether acute psychosocial stress affects loss aversion and reward-cue attentional salience. Sixty-one healthy adults completed the...

Early Mortality in Patients with Biopsy-Only Glioblastoma: Clinical, Radiological and Molecular Predictors from a Retrospective Cohort

Background/Objectives: Patients with unresectable glioblastoma (GBM) undergoing biopsy alone represent a clinically heterogeneous population with poor survival and limited access to standard oncological treatment. We investigated clinical, radiological, and histomolecular factors...

The lived experience of trans persons: a bottom-up review co-written by experts by experience and academics.

We present here the first bottom-up review of the lived experience of trans persons, co-written by experts by experience and academics. We sourced the medical and non-medical literature, focusing on first-person narratives, and critically extracted experiential themes, which were...

Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019–2025

ABSTRACT Background The COVID‐19 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024–2...

Real-world Italian experience with asciminib in chronic myeloid leukaemia–chronic phase: case series and drug profile overview

Abstract Asciminib selectively targets the myristoyl pocket of ABL1, offering high specificity and a potentially improved safety profile. Its efficacy has been demonstrated in both clinical trials and real-world settings, including heavily pretreated patients and those with T315I...

A novel GRN mutation presenting with an amnestic phenotype mimicking early onset Alzheimer disease, a case report

Frontotemporal dementia is a neurodegenerative disease with a variety of clinical presentations. Despite the idiopathic form is the most frequent, it may be often associated with heritable mutations, sometimes characterized by unusual clinical manifestations. Herein we present a...

CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT—a systematic review

Abstract Objective Cardiac extracellular volume (ECV) is a quantitative imaging biomarker of myocardial interstitial expansion and diffuse fibrosis, with cardiac magnetic resonance regarded as the reference standard method for assessment. Interest in computed tomography (CT)-deri...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Defibrillation in refractory cardiac arrest: knowledge gaps and future priorities

PURPOSE OF REVIEW: Refractory shockable cardiac arrest remains associated with poor outcomes despite prompt cardiopulmonary resuscitation and repeated defibrillation. This review summarizes recent evidence on ventricular fibrillation (VF) phenotyping, vector-change (VC) defibrill...

mRNA Vaccines as Novel Immunotherapeutic Approaches in Gastrointestinal Cancers

Messenger RNA vaccines have moved rapidly from the infectious-disease area into oncology. They now represent an attractive therapeutic option for gastrointestinal (GI) cancers. Personalised constructs, designed to elicit tumour-specific T-cell immunity, have shown acceptable safe...

Assessing glymphatic role in the association between choroid plexus enlargement and white matter lesions load: The uncertain path through diffusion tensor imaging along the perivascular space (DTI-ALPS)

Background The choroid plexus (CP) is involved in cerebrospinal fluid production, immune surveillance, and brain fluid homeostasis. CP enlargement has been linked to neuroinflammation, glymphatic dysfunction, and white matter lesion (WML) burden, but the mechanisms underlying the...

Association of three different dietary patterns with the metabolomic profiles of children: the BiomarKid project

Abstract Background and aims Metabolomics offers a promising approach to objectively assess food intake and nutrition-related health risks. Three different dietary patterns (DPs) associated with cardiometabolic health were previously identified at 2 years of age in the EU Childho...

Automated B-lines quantification with lung ultrasound in mechanically ventilated patients

BACKGROUND: If ultrasound dedicated software for the identification and quantification of interstitial syndrome is equal or superior to experts observation is still being explored. The primary objective of this study was to compare the performance of an automatic method based on...