Fondation FondaMental

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

Abstract Gastrointestinal (GI) symptoms are prevalent in Autism Spectrum Disorder (ASD), yet their biological correlates remain poorly understood, notably in adults. The microbiota-derived metabolite p- cresol is reported to be elevated in the urine and stool of ASD patients, but...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

Challenging the predictive coarse-to-fine hypothesis in emotional face perception

Introduction Predictive processing (PP) accounts conceptualize perception as an interaction between top-down predictions and bottom-up sensory inputs. In the visual domain, low spatial frequencies (LSF) convey coarse information, supporting early predictions, refined by high spat...