Fondation FondaMental

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

Challenging the predictive coarse-to-fine hypothesis in emotional face perception

Introduction Predictive processing (PP) accounts conceptualize perception as an interaction between top-down predictions and bottom-up sensory inputs. In the visual domain, low spatial frequencies (LSF) convey coarse information, supporting early predictions, refined by high spat...