First People’s Hospital of Zunyi

First-line immune checkpoint inhibitors versus chemotherapy in delaying quality of life deterioration in advanced NSCLC: a systematic review and meta-analysis

Backgroud: Immune checkpoint inhibitors (ICIs) have transformed first-line treatment for advanced non–small-cell lung cancer (aNSCLC). While overall survival(OS) remains the primary endpoint, health-related quality of life (HRQoL) is a key patient-centered outcome. Time to deteri...

The role of C-reactive protein to lymphocyte ratio and sleep duration in heart failure: exploring the mechanistic interplay and clinical implications

Heart failure (HF) is a progressive disease with complex pathogenesis involving inflammation, immune dysfunction, and metabolic abnormalities. Although C-reactive protein (CRP) is an established HF marker, the CRP-to-lymphocyte ratio (CLR) integrates inflammatory and immune respo...

Ferroptosis and Iron Dyshomeostasis as Drivers of Wound Chronicity in Diabetic Foot Ulcers: Pathophysiological Mechanisms and Targeted Therapeutic Strategies

Background diabetic foot ulcers (DFUs) carry 5-year mortality rates of 50%–70% and recurrence rates of 65% at three to five years. Standard-of-care protocols fail to resolve wound chronicity in a substantial proportion of patients, reflecting incomplete understanding of the cellu...

Sitravatinib combined with osimertinib overcomes acquired osimertinib resistance in NSCLC by targeting AXL and the PI3K/AKT/GSK3β signaling pathway

The emergence of acquired resistance to osimertinib has emerged as a severe plight in the clinical management of patients with advanced harboring epidermal growth factor receptor mutations non-small cell lung (NSCLC). We comprehensively evaluated sitravatinib, an emerging multita...

Identification and experimental validation of biomarkers associated with the Wnt signaling pathway in preeclampsia

Preeclampsia (PE) is a pregnancy disorder associated with hypertension. The Wnt signaling pathway regulates human cell proliferation, migration, and apoptosis. This study aimed to develop a blood-based (non-invasive) diagnostic biomarker panel for PE based on Wnt signaling pathwa...