First People’s Hospital of Zunyi

Cross-national patterns of cardiometabolic disease progression from healthy state to stroke: a cause-specific Cox transition analysis of six international cohorts

Cardiometabolic disease progression to stroke involves intermediate transitions through hypertension (HTN) and diabetes (DM). However, cross-national comparisons of these transition patterns remain unexplored. We compared cardiometabolic progression pathways, including death as a...

Bionic sleep therapy combined with multimodal management for chronic insomnia with alcohol withdrawal-related symptoms

Rationale: Patients who use alcohol as a sleep aid may experience withdrawal-related insomnia and hyperarousal, which can reinforce continued drinking. Bionic sleep therapy (BST) is an exploratory intervention using intravenous anesthetic and sedative agents under close monitorin...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Cost-Utility Analysis of Comprehensive Integrated Management for Psoriasis and Periodontitis: A Markov Cohort Study

Objectives Psoriasis and periodontitis co-occur in Chinese adults beyond chance expectation, sharing proinflammatory pathways. We modelled the long-term economic value of integrating periodontal care into psoriasis management in China. Methods A nine-state Markov cohort model (1-...

CSNK2B-associated epilepsy: family report and literature review

Abstract Background CSNK2B mutations are associated with Poirier-Bienvenu neurodevelopmental syndrome (POBINDS), in which epilepsy is a common clinical feature. To describe the epilepsy phenotype of CSNK2B mutations, we reported a family with a novel CSNK2B mutation, added this i...

Bardoxolone methyl exerts an inhibitory effect on respiratory syncytial virus infection by downregulating IL-6 via the IKKβ/NF-κB signaling pathway

ABSTRACT Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, older adults, and immunocompromised individuals, but therapeutic options for active infection remain limited. Interleukin-6 (IL-6) contributes to RSV replication and RSV-induce...

A succinylation-related machine learning signature reveals prognostic and immune heterogeneity in lung adenocarcinoma

Succinylation is an emerging post-translational modification involved in tumor metabolism and progression. However, the role of succinylation-related genes (SRGs) in lung adenocarcinoma (LUAD) remains poorly understood. This study aimed to systematically investigate the prognosti...

Association between serum lactate trajectories and short-term mortality in pediatric acute kidney injury patients

OBJECTIVE: Acute kidney injury (AKI) is a life-threatening condition in children. Serum lactate is a critical indicator of oxygen metabolism and tissue hypoperfusion. This study investigated the association between early dynamic lactate trajectories during pediatric intensive car...

Novel Compound Heterozygous STK4 Variants Associated with Combined Immunodeficiency, Impaired Thymic Output, and Altered FOXO1-BACH2 Signaling

Serine/threonine kinase 4 (STK4) deficiency is a rare combined immunodeficiency (CID). This study aims to analyze the clinical and immunological characteristics of a child carrying novel compound heterozygous STK4 variants and to explore potential alterations in FOXO1-BACH2 signa...

First-line immune checkpoint inhibitors versus chemotherapy in delaying quality of life deterioration in advanced NSCLC: a systematic review and meta-analysis

Backgroud: Immune checkpoint inhibitors (ICIs) have transformed first-line treatment for advanced non–small-cell lung cancer (aNSCLC). While overall survival(OS) remains the primary endpoint, health-related quality of life (HRQoL) is a key patient-centered outcome. Time to deteri...

The role of C-reactive protein to lymphocyte ratio and sleep duration in heart failure: exploring the mechanistic interplay and clinical implications

Heart failure (HF) is a progressive disease with complex pathogenesis involving inflammation, immune dysfunction, and metabolic abnormalities. Although C-reactive protein (CRP) is an established HF marker, the CRP-to-lymphocyte ratio (CLR) integrates inflammatory and immune respo...

Ferroptosis and Iron Dyshomeostasis as Drivers of Wound Chronicity in Diabetic Foot Ulcers: Pathophysiological Mechanisms and Targeted Therapeutic Strategies

Background diabetic foot ulcers (DFUs) carry 5-year mortality rates of 50%–70% and recurrence rates of 65% at three to five years. Standard-of-care protocols fail to resolve wound chronicity in a substantial proportion of patients, reflecting incomplete understanding of the cellu...

Sitravatinib combined with osimertinib overcomes acquired osimertinib resistance in NSCLC by targeting AXL and the PI3K/AKT/GSK3β signaling pathway

The emergence of acquired resistance to osimertinib has emerged as a severe plight in the clinical management of patients with advanced harboring epidermal growth factor receptor mutations non-small cell lung (NSCLC). We comprehensively evaluated sitravatinib, an emerging multita...

Identification and experimental validation of biomarkers associated with the Wnt signaling pathway in preeclampsia

Preeclampsia (PE) is a pregnancy disorder associated with hypertension. The Wnt signaling pathway regulates human cell proliferation, migration, and apoptosis. This study aimed to develop a blood-based (non-invasive) diagnostic biomarker panel for PE based on Wnt signaling pathwa...