First People's Hospital of Yunnan Province

Targeted RNA m5C demethylation of NFE2L2 mRNA by dCas13b-TET2 restores ferroptosis and overcomes cisplatin resistance in bladder cancer

Cisplatin-based chemotherapy remains a cornerstone for the treatment of advanced bladder cancer; however, the emergence of resistance severely limits its clinical efficacy. Ferroptosis suppression has been implicated in chemotherapy resistance, yet the upstream epitranscriptomic...

Esophageal cancer burden across 48 Asian locations, 2009–2023: demographic decomposition and exploratory projections

Asia carries most of the global esophageal cancer burden, but trends in rates may differ from changes in service demand. We assessed burden across 48 Asian locations during 2009–2023. We analyzed Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 estimates of...

ANGPTL4 is a hypoxia associated candidate linked to immune and vascular phenotypes in ccRCC

Clear cell renal cell carcinoma (ccRCC) is characterized by prominent vascularization and cellular heterogeneity, but reliable biomarkers for angiogenesis and response to targeted therapy remain limited. In this study, transcriptomic data from GEO cohorts (GSE53757, GSE66271, GSE...

Application of symptom network analysis among patients with gastric cancer: A scoping review

Objective To map evidence on symptom network analysis in patients with gastric cancer by summarizing study characteristics, commonly used assessment tools, central and bridge symptoms, temporal symptom relationships, and associated factors, and to provide a basis for precision sy...

Beyond static uptake: rethinking [18F]FMISO PET for quantifying and interpreting tumor hypoxia

Abstract Background Tumor hypoxia is a critical microenvironmental determinant of progression, treatment resistance, and prognosis in solid tumors. Among hypoxia-targeted imaging approaches, [ 18 F]fluoromisonidazole ([ 18 F]FMISO) positron emission tomography (PET) provides a no...

Differential modulation of ferroptosis pathways by NOX1/4 and NLRP3 inhibition in DSS-induced colitis

Ferroptosis contributes to the pathogenesis of inflammatory bowel disease, but how NOX1/4 and NLRP3 pathways regulate this process remains unclear. This study aimed to investigate the therapeutic effects and mechanisms of the NOX1/4 inhibitor Setanaxib (SET) and the NLRP3 inhibit...

Ellagic Acid Enhances RSL3 ‐Induced Ferroptosis by Inhibiting the Nrf2/ HO ‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) exhibits profound therapeutic resistance due to redox adaptation, particularly through Nrf2/HO-1 pathway activation. Ferroptosis induction via GPX4 inhibitors (e.g., RSL3) is promising but limited by adaptive antioxidant responses. Ellagic...

Smad6-mediated suppression of TGF-β/BMP signaling facilitates oocyte extract-induced reprogramming

Abstract Stem cells serve as foundational seed cells in regenerative medicine, yet their limited availability remains a significant constraint. The emergence of somatic cell reprogramming has provided a promising alternative for generating pluripotent stem cells. However, challen...

The comprehensive detection of hemoglobinopathy variants via long-read sequencing

ABSTRACT BACKGROUND The genetic complexity of hemoglobin genes, characterized by high GC content and homologous sequences, poses significant challenges for detecting hemoglobin variants in clinical settings. METHODS A long-read indexed PCR method utilizing the novel CycloneSEQ na...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

Identification and experimental validation of biomarkers associated with the Wnt signaling pathway in preeclampsia

Preeclampsia (PE) is a pregnancy disorder associated with hypertension. The Wnt signaling pathway regulates human cell proliferation, migration, and apoptosis. This study aimed to develop a blood-based (non-invasive) diagnostic biomarker panel for PE based on Wnt signaling pathwa...

Escitalopram for psychological symptoms and cardiovascular outcomes in patients with coronary heart disease: a systematic review and meta-analysis of randomized controlled trials

Patients with coronary heart disease (CHD) often have comorbid depression and anxiety, which worsen prognosis. Escitalopram, a selective serotonin reuptake inhibitor, is used for these symptoms, but evidence on its psychological and cardiovascular effects in CHD is limited. This...