First People's Hospital of Yunnan Province

The comprehensive detection of hemoglobinopathy variants via long-read sequencing

ABSTRACT BACKGROUND The genetic complexity of hemoglobin genes, characterized by high GC content and homologous sequences, poses significant challenges for detecting hemoglobin variants in clinical settings. METHODS A long-read indexed PCR method utilizing the novel CycloneSEQ na...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

Identification and experimental validation of biomarkers associated with the Wnt signaling pathway in preeclampsia

Preeclampsia (PE) is a pregnancy disorder associated with hypertension. The Wnt signaling pathway regulates human cell proliferation, migration, and apoptosis. This study aimed to develop a blood-based (non-invasive) diagnostic biomarker panel for PE based on Wnt signaling pathwa...

Escitalopram for psychological symptoms and cardiovascular outcomes in patients with coronary heart disease: a systematic review and meta-analysis of randomized controlled trials

Patients with coronary heart disease (CHD) often have comorbid depression and anxiety, which worsen prognosis. Escitalopram, a selective serotonin reuptake inhibitor, is used for these symptoms, but evidence on its psychological and cardiovascular effects in CHD is limited. This...