First People's Hospital of Kunshan

IRP1 affects the long-term survival and function of iTregs by regulating ferroptosis and apoptosis

As an important classification of Tregs, iTregs play a critical role in inducing transplant immune tolerance. Iron metabolism is closely linked to iTreg function, and IRP1 serves as a central regulator of cellular iron homeostasis. However, the relationship between IRP1 and iTreg...

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Alcoholic hepatitis (AH) is a liver disease caused by long-term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis. Kupffer cells are liver resident macrophages and the effect of glycolytic reprogramm...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Context-dependent functional diversity of dorsomedial posterior parietal neurons revealed by single-unit fMRI mapping during naturalistic viewing

Abstract The dorsomedial posterior parietal cortex (dmPPC) plays an important role in episodic processing by integrating sensory, cognitive, and motor information across distributed brain systems. However, how individual dmPPC neurons participate in large-scale functional organiz...

Pharmacological inhibition of Alistipes putredinis-derived indole-3-acetic acid by baicalin suppresses stress-driven breast cancer metastasis

Breast cancer patients often experience chronic stress disorders and gut dysbiosis. Baicalin has been demonstrated to have antitumor, antibacterial and microbiota regulatory functions and can be used for treating breast cancer and preventing metastasis; however, how baicalin regu...

Machine learning identifies ac4C-related prognostic signature and TUBA1C as therapeutic target in COAD

To explore the role of N4-acetylcytidine (ac4C)-related genes (acRGs) in colon adenocarcinoma (COAD) and identify reliable prognostic biomarkers and potential therapeutic targets. Multi-source transcriptomic datasets (TCGA-COAD, GSE39582, GSE17536) and single-cell RNA-seq data we...

Association of systemic inflammatory indices NLR, SIRI, and MHR with carotid plaque in middle-aged and older adults: a retrospective cross-sectional study

To examine the associations of the neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with carotid plaque in middle-aged and older adults. This retrospective cross-sectional study inc...

Diagnostic value of CT-quantified abdominal fat parameters for metabolic dysfunction-associated fatty liver disease

To analyze the diagnostic value of CT-derived abdominal fat indices in predicting MAFLD and establish an integrated diagnostic system. A retrospective study on 174 patients with a previous history of abdominal CT examination in our institute between January 2022 and June 2024 was...

The genetic architecture of the CSF-contacting nucleus in mice and the screening of its key target via CSF pathway for mediating neuropathic pain

The cerebrospinal fluid (CSF)-contacting nucleus has been well characterized in rats and macaques but not yet precisely defined in mice. This study aims to provide a comprehensive description of the location, adjacent structures, cell morphology, spatial imaging, and genetic arch...