First People's Hospital of Jingzhou

Association of a nurse-coordinated lifestyle management clinic with 1-year changes in liver enzymes and fibrosis-4 index in patients with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched cohort study

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disease for which lifestyle modification remains a central component of management. However, real-world evidence regarding structured nurse-coordinated lifestyle management in outpatient MA...

Adjuvant anti-TIGIT plus anti-PD-1 in melanoma: A necessary failure that clarifies the path forward

The phase 3 KEYVIBE-010 trial investigated adjuvant vibostolimab (anti-TIGIT) plus pembrolizumab versus pembrolizumab alone in resected stage IIB–IV melanoma. At the first interim analysis, the combination met futility criteria, with a recurrence-free survival hazard ratio of 1.2...

H&E to recurrence score: A step forward, but not yet a substitute for genomic testing

Shamai and colleagues developed a multimodal deep-learning model that predicts Oncotype DX recurrence scores from routine H&E slides and clinicopathological variables in hormone receptor‑positive, HER2‑negative early breast cancer. Validated across the TAILORx trial and six exter...

The divergent management of melasma: a 2026 clinical review comparing traditional standards in lighter photo types to novel athermal and biological modalities in Fitzpatrick IV–VI

Melasma (historically chloasma) remains a complex, recalcitrant pigmentary disorder affecting millions worldwide. This article elucidates the paradigm shift in management strategies observed in early 2026 for Fitzpatrick III-VI, its comparison with Fitzpatrick I–III, and the tran...

Network analysis of frailty, sleep quality, and life satisfaction in older patients: a cross-sectional study stratified by chronic disease burden

Abstract Background Multimorbidity and chronic disease burden are common among older patients and are closely associated with frailty, poor sleep, and reduced subjective well-being. However, total-score-based analyses may obscure item-level interactions across health domains. Thi...