First People's Hospital of Foshan

Development of a urine-based DNA methylation assay for early endometrial cancer detection: a multicenter diagnostic study

Endometrial cancer (EC) incidence is rising globally, yet diagnosis still depends on invasive procedures, which limit accessibility and delay early detection. A noninvasive, accurate, and accessible diagnostic assay is urgently needed to enable early EC detection. In this multice...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Exploring multidimensional cfDNA methylation fragmentomics for non-invasive postoperative assessment in early-stage lung cancer

Background Effective postoperative monitoring remains an important area of investigation for early-stage lung cancer patients after curative resection. This exploratory technical feasibility study evaluated a methylation-based fragmentomics approach by analyzing paired pre- and p...

Cardiac MR Characterization of Infarct‐Related and Remote Myocardial Injury in Multivessel Disease After Acute Myocardial Infarction

BACKGROUND: Patients with multivessel disease (MVD) after acute myocardial infarction (AMI) have worse outcomes than those with single-vessel disease (SVD), but whether MVD is associated with diffuse myocardial injury beyond the infarct zone (IZ) remains unclear. PURPOSE: To char...

The relationships of parenting styles, self-esteem and rejection sensitivity: a latent profile analysis

Abstract Background A large number of theoretical reasoning and empirical studies have shown that both parenting style and self-esteem have an impact on the formation of rejection sensitivity, and there may be more complex mechanisms between the above variables. This study aims t...