Institution
First Hospital of Xi'an
Recent research
- Health & MedicineOpen access
In the management of muscle-invasive urothelial carcinoma, radiotherapy serves as an important adjuvant treatment to radical cystectomy. Evidence from other cancers indicates that synchronous chemoradiotherapy is associated with enhanced local control and survival outcomes when c...
- Health & MedicineOpen access
Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism
Abstract As organisms age, mitochondrial metabolic activity declines, and disrupted gene expression regulation mediated by histone acetylation induces the emergence of senescent physiological phenotypes in tissues. In this study, we found that periodic exposure to red light signi...
- Health & MedicineOpen access
Abstract Background Tumor budding (TB) is a clinically important prognostic marker in colorectal cancer (CRC), but its assessment remains subjective and its biological basis is incompletely understood. We developed an artificial intelligence (AI)-based TB evaluation framework and...
- Health & MedicineOpen access
LOX-1 promotes cardiac hypertrophy via p38MAPK signaling in alcoholic cardiomyopathy
Cardiac hypertrophy is a hallmark of alcoholic cardiomyopathy (ACM). The role of Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)/p38MAPK in mediating hypertrophy in ACM remains unclear. Primary neonatal rat ventricular cardiomyocytes (pNRVMs) were treated with eth...
- Health & MedicineOpen access
Abstract Background Reconstruction of critical-sized proximal femoral defects caused by high-energy trauma remains a formidable orthopedic challenge due to compromised mechanical stability, anatomical complexity, and limited biological integration capacity. Traditional methods (a...