First Hospital of Jiaxing

Effect of Adjunctive Mifepristone Pre-treatment on Operative Efficiency and Postoperative Recovery in Cesarean Scar Pregnancy Undergoing Curettage After Uterine Artery Embolization

AIM: This study aims to evaluate whether short-course mifepristone pre-treatment improves procedural efficiency and early recovery after uterine artery embolization (UAE), followed by dilation and curettage (D&C) for cesarean scar pregnancy.METHODS: This retrospective study recru...

Multiple-Staged Versus Single-Stage Surgical Excision for the Reconstruction of Congenital Melanocytic Nevi: A Meta-Analysis of Efficacy and Safety

AIM: Systematic evidence comparing multiple-staged and single-stage excision strategies for the excision and reconstruction of congenital melanocytic nevi (CMN) remains limited. Because direct comparative evidence remains scarce, we pooled available studies to determine whether m...

Repeat pulmonary resection for multiple primary lung cancer: perioperative safety and long-term oncological outcomes

With widespread low-dose CT screening, multiple primary lung cancer (MPLC) diagnoses have markedly increased. Surgical resection remains the preferred treatment; however, repeat pulmonary resection is technically demanding due to pleural adhesions and altered anatomy from prior s...

Sphingomyelin (30:1; O2) as a novel lipid biomarker associated with the diagnosis of intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a primary hepatic malignancy with an incidence second only to hepatocellular carcinoma (HCC). Preoperative differentiation between ICC and HCC remains challenging in certain cases. This study aimed to identify potential diagnostic lipid bi...

TL1A promotes microglial inflammatory response via DR3-NF-κB signaling to mediate the progression of postoperative cognitive dysfunction

Aim To investigate the mechanism by which tumor necrosis factor ligand-related molecule 1 A (TL1A) promotes the progression of postoperative cognitive dysfunction (POCD). Methods A POCD mouse model was established by splenectomy. Cognitive and behavioral abilities of mice were as...

A multi-biomarker approach for discrimination of angiographically detected coronary artery disease in metabolic dysfunction-associated steatotic liver disease: the utility of routine laboratory indices

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a globally prevalent chronic liver disease. Accumulating evidence indicates that MASLD is closely linked to coronary artery disease (CAD) through the liver-heart axis, with insulin resistance,...

The natural course of pediatric epididymal cysts during puberty: resolution trends and predictive value of baseline size

Epididymal cysts represent a frequent benign scrotal finding in boys, yet their natural history throughout the pubertal transition remains insufficiently understood. Current clinical guidance is largely derived from adult data, and objective predictors of spontaneous regression d...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Helicobacter pylori-related peptic ulcer presenting as isolated iron deficiency anemia without typical gastrointestinal complaints in a child: a case report

Iron deficiency anemia (IDA) is the most common form of nutritional anemia in children worldwide. Helicobacter pylori (H. pylori) infection is a well-recognized contributor to pediatric IDA, through mechanisms including bleeding from peptic ulcers or erosions and impaired iron ab...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Association Between Air Pollution and Psoriasis-Related Outcomes: A Systematic Review and Meta-analysis

Skin diseases are a group of consequences due to exposure to air pollution that have received less attention. Among these diseases, the relationships between short-term and long-term exposure to air pollutants and psoriasis remain uncertain. The present systematic review and meta...

Bibliometric analysis of stroke centers

Objective: To conduct a bibliometric analysis of stroke center-related research fields, both domestically and internationally, using CiteSpace, and to explore the current research status, hot topics, and development trends. Methods: Using the China National Knowledge Infrastructu...

The imaging features of neurovascular compression in hemifacial spasm patients

Neurovascular compression is considered the main cause of primary hemifacial spasm. However, it also occurs on the asymptomatic facial nerves in primary hemifacial spasm patients and in healthy controls. This study aimed to compare neurovascular compression features among the thr...

An expert-level generalist AI for abdominal CT diagnosis

Artificial intelligence (AI) in radiology aspires to deliver expert-level diagnosis across diverse clinical tasks, yet existing supervised strategies remain limited in scope. We developed RADAR, a generalist vision-language model trained on more than 400,000 contrast-enhanced abd...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Effects of N Reduction and Combined with Organic Fertilizer Application on Rice Yield and NH3 Volatilization from Saline Soil

Organic fertilizer (OF) application can significantly enhance soil fertility and crop yield. However, its influence on nitrogen (N) loss via ammonia (NH3) volatilization from reclaimed coastal paddy soil is not well known. We conducted a pot experiment here using cyanobacteria co...

Keratin conversion signature (KRT13/KRT4) defines a high-risk pancreatic cancer subtype with extensive malignant phenotypes

Pancreatic cancer has a poor prognosis. This study investigated the prognostic role of the keratin gene family and aimed to develop a keratin-based biomarker. Bioinformatics analysis was performed using RNA-seq data from gemcitabine-treated patients in the TCGA-PAAD cohort (disco...

An engineered pneumolysin ΔA146 derivative induces apoptosis in breast cancer cells: an in vitro proof-of-concept for antibody-drug conjugate payload development

The therapeutic potential of antibody-drug conjugates (ADCs) is frequently undermined by the emergence of resistance to conventional payloads, which predominantly exert their effects through the disruption of intracellular targets such as microtubules or nuclear DNA. In pursuit o...

Identification of Vital Genes Common to Dilated and Hypertrophic Cardiomyopathy Using Machine Learning and Bioinformatics.

BACKGROUND: Heart failure (HF) is a complex clinical syndrome and a leading cause of hospitalization and mortality worldwide, with significantly increasing mortality rates over time. Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are 2 major myocardial disease...