First Hospital of China Medical University

Gastric serum biomarkers for long-term risk stratification of gastric and extra-gastric cancers: a 26-year cohort study

Gastric serum biomarkers are established for gastric cancer risk assessment, but their utility for extra-gastric malignancies and long-term risk stratification remains unexplored. We prospectively evaluated serum pepsinogens (PGI, PGII), gastrin-17 (G-17) and anti- H. pylori IgG...

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Abstract Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OTUD5 in pathological cardiac hypert...

Cardiovascular Magnetic Resonance for Early Detection of Cancer Therapy-Related Cardiac Dysfunction: From Multiparametric Tissue Signatures to Clinical Pathways

Cancer therapy-related cardiac dysfunction (CTRCD) can compromise cardiovascular health and the delivery of anticancer treatment. Echocardiography and cardiac biomarkers remain the first-line surveillance tools; cardiovascular magnetic resonance (CMR) provides complementary asses...

LncRNA RBMS3-AS3 promotes ovarian cancer progression by regulating QKI and RBFOX2

Long non-coding RNAs (lncRNAs) exert pivotal regulatory functions in the malignant progression of ovarian cancer. Despite this, the biological roles and underlying molecular mechanisms of lncRNA RBMS3-AS3 in ovarian cancer pathogenesis have yet to be fully elucidated. RBMS3-AS3 i...

Preclinical characterization and first-in-human phase I dose-escalation results with JYB1907, a novel anti-GARP-TGF-β1 complex monoclonal antibody in patients with advanced solid tumors

Transforming growth factor-β1 (TGF-β1) promotes immunosuppression in the tumor microenvironment via the GARP-latent TGF-β1 complex on regulatory T cells. JYB1907 is a humanized IgG4 monoclonal antibody targeting this complex. Preclinically, JYB1907 bound GARP-latent TGF-β1 comple...

Molecular mechanism of S100A11 inhibiting anti-HCC immune function of NK cells

Objective To explore the regulatory role and underlying molecular mechanism of S100A11 in the anti-hepatocellular carcinoma (HCC) function of natural killer (NK) cells, and to provide a novel target and theoretical basis for optimizing immunotherapy for HCC. Methods The expressio...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Gut microbiome features in methamphetamine use disorder: external validation of a candidate marker panel and exploratory multi-omics associations

Abstract Methamphetamine use disorder (MUD) is a chronic, relapsing disorder with symptoms most pronounced during withdrawal, yet objective biomarkers remain lacking. Although gut microbial alterations have been reported in substance use disorders, their potential as candidate ma...

PAK4 exacerbates melanoma immunosuppression by promoting exosome release

Melanoma remains a lethal malignancy with frequent resistance to immune checkpoint blockade therapy. Clinical evidence associates elevated PAK4 expression with poor response to anti-PD-1 treatment in melanoma patients. While tumor-derived exosomes are recognized as key immunosupp...

Kidney Transplant Recipients’ Experiences of Sleep and Coping Strategies: An Interpretative Phenomenological Study

ABSTRACT Objective To explore the lived experiences of sleep disturbances and coping among kidney transplant recipients (KTRs), thereby providing a basis for developing individualized and targeted nursing interventions. Methods A qualitative study using Interpretative Phenomenolo...

CD4+ cytotoxic T cells: context-dependent effectors in health and disease

Abstract Cytotoxic CD4 + T cells (CD4 + CTLs) have been identified as a specialized effector population characterized by potent cytotoxic machinery, including granzymes, perforin, and the Fas/FasL pathway, that enables the direct killing of MHC-II-expressing target cells. In addi...

Targeting Tumor–CAFs Crosstalk to Reverse Drug Resistance and Immunosuppression Through Cuproptosis

ABSTRACT Chemotherapy resistance and immunosuppression are the current key bottlenecks in tumor treatment. In the tumor microenvironment (TME), cancer‐associated fibroblasts (CAFs) secrete dense extracellular matrix and various immunosuppressive factors, forming a dynamic “tumor–...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Digital health interventions across the cancer control continuum: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials

Given the rising global cancer burden and fragmented evidence on digital health interventions (DHIs), this umbrella review synthesizes evidence on DHIs across the cancer control continuum to inform evidence-based practice. We systematically searched PubMed, Medline (via Ovid), We...

A web-based interpretable machine learning model for immediate postoperative delirium risk stratification in elderly patients undergoing colorectal cancer surgery

Postoperative delirium (POD) is a serious complication among elderly patients undergoing colorectal cancer surgery, yet accurate and clinically interpretable risk stratification remains challenging. This study aimed to develop and validate an interpretable machine learning (ML) m...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Community Interactions and Extracellular Riboflavin Are Associated with Oral Biofilm-Mediated Medical Stainless Steel Corrosion

Microbiologically influenced corrosion (MIC) at oral biomaterial interfaces is viewed as an ecological phenomenon, yet how microbial composition and interspecies interactions shape corrosion remains unclear. Here, we investigated whether oral microbial community composition and i...

STAT3/NF-κB signaling axis in macrophage and myeloid-derived suppressor cell driven immune evasion in lung cancer

Immune checkpoint blockade (ICB) has brought transformative advances to lung cancer management; nevertheless, immunosuppressive tumor microenvironment (TME)-mediated therapeutic resistance constitutes a prominent unsolved bottleneck, mainly originating from the sustained buildup...

Real‐World Glycemic Outcomes of Open‐Source Automated Insulin Delivery During 12 Months Among People With Type 1 Diabetes Across Age Groups

ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people wi...