First Bethune Hospital of Jilin University

Paradoxical Association of Body Mass Index With Occurrence and Mortality of Venous Thromboembolism in Hospitalized Patients: A National Hospital‐Based Cohort Analysis

Background The association between body mass index (BMI) and venous thromboembolism (VTE) occurrence and mortality is controversial. This study aimed to investigate the association of BMI with VTE occurrence and mortality and explore the consistency across age, sex, and medical s...

Peritumoral Malignant Cellular Foci Performs Better Than Tumor Budding and Poorly Differentiated Cluster in Risk Stratification of Lymph Node Metastasis in pT1 Colorectal Cancer

As biomarkers separated by the arbitrary 5-tumor-cell cutoff at the tumor invasive front, tumor budding (TB) and poorly differentiated clusters (PDC) are recognized as high-risk factors for lymph node metastasis (LNM) in pT1 colorectal cancer (CRC). Nonetheless, relevant findings...

An oncolytic virus armed with fowl adenovirus fiber-modified recombinant TRAIL enhances tumor targeting and immunotherapy activity

Oncolytic viruses have emerged as a promising strategy in cancer immunotherapy and have been applied to the treatment of various tumors. We previously demonstrated that oncolytic adenoviruses engineered expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) co...

Levosimendan can effectively reduce myocardial cell apoptosis caused by hypoxia through antioxidant activity

Abstract Levosimendan (LMSD) is a novel positive inotropic drug with unique chemical structure and pharmacological properties. It has multiple effects such as dilating blood vessels and improving myocardial diastolic function, and is widely used in the treatment of cardiovascular...