First Affiliated Hospital of Xinxiang Medical University

Constrained endurance in long-term family caregiving: Rethinking resilience through nursing ethics

Resilience is an established concept in family-caregiver research, where it is used to describe how caregivers maintain functioning and adapt to sustained adversity. In long-term family care for older adults with disabilities, however, resilience is ethically ambiguous. Continued...

The AURKA–PTTG1 signaling axis induces enzalutamide resistance in prostate cancer

Background Prostate cancer (PCa), a common male malignant tumor, often develops resistance to the androgen receptor inhibitor enzalutamide (ENZ). Despite its established oncogenic role, pituitary tumor-transforming gene 1 (PTTG1)’s specific function and regulatory mechanism in EN...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...