First Affiliated Hospital of Xinjiang Medical University

Health inequalities in the global reproductive-age population: GBD 2021 trends and female-male differences, 1990–2021

Socioeconomic health inequality among reproductive-age populations remains insufficiently characterized globally. Using GBD 2021 data for individuals aged 15–49 years in 204 countries and territories, we assessed disability-adjusted life year (DALY) rates and quantified absolute...

Automated deep learning-based comprehensive assessment of stent in intravascular optical coherence tomography

The process of manually identifying and quantifying coronary stents in intravascular optical coherence tomography (IVOCT) images is time-consuming and subjective. In this study, a deep learning-based target recognition model, SMA-YOLO, was developed for automatic identification a...

The early-onset pancreatic cancer paradox: a systematic review and meta-analysis

BACKGROUND: Globally, the rate of early-onset pancreatic cancer (EOPC) is increasing, but its clinical features and outcomes relative to average-onset pancreatic cancer (AOPC) remain uncertain. We compared clinicopathological features, treatment patterns, and survival outcomes. M...

Impaired fatty acid oxidation and mitochondrial injury mediated by the AMPK/PPARα pathway: A key mechanism in high-fat diet-aggravated ulcerative colitis

Background A high-fat diet (HFD) is closely associated with the progression of ulcerative colitis (UC). However, the underlying mechanisms, particularly the interplay among lipid metabolic disturbances, mitochondrial damage, and intestinal barrier dysfunction, remain poorly defin...

Association between controlling nutritional status score and left ventricular hypertrophy in adults

Left ventricular hypertrophy (LVH) is an important marker of cardiovascular risk, while malnutrition is common among adults. The Controlling Nutritional Status (CONUT) score is an objective tool for nutritional assessment. This study aimed to investigate the associations of CONUT...

Integrating single-cell RNA sequencing with Visium HD spatial atlas reveals immune–stromal cell interactions in Echinococcus multilocularis metacestode infection

Abstract Background Alveolar echinococcosis (AE), caused by the larval stage of the tapeworm Echinococcus multilocularis , is a fatal zoonotic disease characterized by progressive hepatic granulomatous inflammation and fibrosis. However, the mechanisms underlying the pathological...

WEM-Mamba: a Wavelet-Enhanced MedMamba framework for rotator cuff tear classification in X-ray images

Rotator cuff tear is a common cause of shoulder pain and functional impairment, and its accurate identification is of great significance for clinical treatment decisions. Magnetic Resonance Imaging (MRI) is generally regarded as the important imaging modality for evaluating soft...

Multidimensional analysis on the potential of cell cycle-related gene STMN1 as a tumor biomarker

STMN1 is a critical microtubule-destabilizing protein that controls cell division and cytoskeleton dynamics and participates in tumor initiation and progression. Nevertheless, systematic pan-cancer research on its function, clinical significance and therapeutic value is still lac...

Association of hyperchloremia with mortality and acute kidney injury in critically ill children: a systematic review and meta-analysis

Abstract Background Blood chloride disturbances are common in critically ill children. However, the prognostic significance of hyperchloremia remains uncertain because serum chloride abnormalities may be confounded by the severity of the underlying illness. This systematic review...

Cholesterol sulfate as a novel theranostic target for sepsis-induced liver injury through Beclin1-mediated autophagy enhancement and pyroptosis suppression

Sepsis remains a life-threatening syndrome, and septic liver injury is a frequent and critical complication for which no specific pharmacological therapy exists. Current biomarkers lack sufficient specificity for early diagnosis and severity assessment, highlighting an urgent nee...

Identification and mechanistic study of metabolic-immune subtypes in COPD based on integrated transcriptomic-metabolomic analysis

This study aimed to characterize immune cell metabolic alterations and their regulatory mechanisms in chronic obstructive pulmonary disease (COPD), and to identify metabolism-related immune subtypes associated with lung dysfunction to support immunometabolic classification and ta...

Association between subjective well-being and the risk of cardiometabolic multimorbidity in older Chinese adults: effect modification by the integrated healthy lifestyle score

This study aimed to ascertain the association between subjective well-being (SWB) scores and the cardiometabolic multimorbidity (CMM) risk, and evaluate the potential modifying effect of integrated healthy lifestyle scores among older Chinese adults. A prospective cohort study wa...

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

ABSTRACT The treatment of diabetic wounds remains a major challenge due to persistent bacterial infections, chronic inflammation, and impaired angiogenesis. To address these issues, we develop an immunomodulatory and antibacterial hydrogel integrating epidermal growth factor (EGF...

Early SOX9 Activation Primes Hippo– YAP / TAZ Rewiring During Glioblastoma Stemness Acquisition

Glioblastoma progression is driven by stemness acquisition and cellular plasticity, yet the temporal and spatial organization of these processes remains incompletely defined. In this study, single-cell RNA sequencing, pseudotime reconstruction, spatial transcriptomics, and in vit...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Predictive model for mild cognitive impairment risk in community-dwelling older adults with depressive symptoms based on explainable machine learning: a cross-sectional study

Abstract Background: Mild cognitive impairment (MCI) represents a high-risk prodromal stage of Alzheimer’s disease, and its prevalence and conversion risk are higher among community-dwelling older adults presenting with depressive symptoms. Currently, there is a lack of interpret...

Stress hyperglycaemia ratio and post‐operative delirium after cardiac surgery: a retrospective cohort study of the MIMIC ‐ IV database

Abstract Background Post‐operative delirium is a serious neurocognitive complication of cardiac surgery. The stress hyperglycaemia ratio (SHR), which adjusts acute glucose levels to baseline glycaemia using glycated haemoglobin, has demonstrated superior prognostic value in criti...

Experimental evaluation of Nilotinib and Paclitaxel co-delivered via albumin nanoparticles as a therapeutic strategy for lung squamous cell carcinoma

Chemotherapy remains the primary treatment for advanced lung squamous cell carcinoma (LUSC); however, its severe toxic side effects significantly limit therapeutic efficacy. There is an urgent clinical need to integrate molecular targeting with chemotherapy to enhance treatment o...

FABP4 and L-acetylcarnitine as candidate biomarkers for small airway dysfunction in children with obese type 2 asthma: a pilot cross-sectional multi-omics study

Childhood obesity-associated asthma represents a distinct phenotype with incompletely understood metabolic mechanisms. This hypothesis-generating study aimed to screen candidate biomarkers associated with small airway dysfunction in children with obese type 2 asthma and explore p...

Methionine addiction in oral squamous cell carcinoma: a metabolic vulnerability targeted by engineered bacteria

Metabolic reprogramming is a defining hallmark of malignant transformation, and tumor-specific amino acid addiction has emerged as a promising therapeutic axis for precision oncology. Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy marked by limited...