First Affiliated Hospital of Wannan Medical College

Serial echocardiographic changes in left ventricular size and calculated mass after transcatheter aortic valve replacement for predominant native aortic regurgitation without severe aortic stenosis: a retrospective cohort study

Left ventricular end-diastolic diameter (LVEDD) is widely available but is one-dimensional and load dependent. We evaluated serial LV size and calculated LV mass after TAVR for predominant native aortic regurgitation (AR) without severe aortic stenosis (AS), using all quantitativ...

A case report of rare primary extraosseous Ewing sarcoma of the bladder is presented, with confirmation by pathological, immunohistochemical, and molecular analyses

Extraosseous Ewing sarcoma (EES) of the bladder is an extremely rare, highly aggressive small round cell malignancy. Because its clinical manifestations and imaging features are nonspecific and its histological appearance closely mimics that of other small round cell tumors, misd...

SNX4 promotes glioblastoma progression through the TGFβ1/Smad signaling pathway and represents a potential therapeutic target

Abstract Background Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor that still lacks highly specific and clinically effective molecular targets for GBM treatment. Sorting Nexin 4 (SNX4) is an important regulatory molecule involved in intracellular membrane...

Factors associated with early hematoma expansion in intracerebral hemorrhage and the value of non-contrast computed tomography imaging features combined with clinical data for early identification

PURPOSE: Early hematoma expansion (HE) after intracerebral hemorrhage (ICH) critically affects patient outcomes. Identifying HE risk using emergency non-contrast computed tomography (NCCT) features and clinical data is important for early risk stratification and evaluation. This...

Association between PCSK9 and post-stroke cognitive impairment: a retrospective cohort study and predictive models establishment based on machine learning

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained increasing attention due to its involvement in lipid metabolism and neuroinflammation regulation. High PCSK9 levels are linked to an elevated risk of cerebrovascular events and small vessel diseases. However, system...