First Affiliated Hospital of Wannan Medical College

Bilayer Polycaprolactone (Mitomycin C)/Poly(L-Lactic Acid)/Gelatine (Dimethyloxalylglycine) Nanofibres for Diabetic Wound Repair

Background: Diabetic skin wounds arise from chronic hyperglycaemia, peripheral neuropathy, microvascular dysfunction, and compromised immunity. Chronic ulcers are further complicated by infection and local ischaemia–hypoxia, which collectively impede tissue repair. Conventional i...

Differential effects of PM2.5 constituents on tuberculosis infection and disease progression in 40,379 student close contacts

Abstract Rationale Outdoor PM2.5 has been increasingly implicated in tuberculosis, yet evidence has largely focused on total PM2.5 mass and has usually considered Mycobacterium tuberculosis (M. tuberculosis) infection and active tuberculosis separately. Whether specific PM2.5 che...

HLA-DMA depletion suppresses malignant glioma phenotypes and murine H2-DMa knockdown enhances the response to anti-PD-1 therapy

Glioblastoma (GBM) exhibits poor responsiveness to immune checkpoint blockade, largely due to an immunosuppressive tumor immune microenvironment. Tumor-associated macrophage (TAM) polarization critically regulates antitumor immunity, yet the role of human leukocyte antigen class...

Association between the C-reactive protein–triglyceride glucose index combined with waist circumference and incident cardiovascular disease across frailty states: a prospective cohort study from CHARLS

The C-reactive protein–triglyceride–glucose index combined with waist circumference (CTI-WC) integrates central adiposity, systemic inflammation, and metabolic dysfunction. It has been associated with incident cardiovascular disease (CVD), but whether this association differs acr...

Effect Modification of Rescue Stenting in ICAS-Related Middle Cerebral Artery Occlusion: The Role of Thrombectomy Failure, Stenosis Severity, and ASPECTS

Rescue stenting (RS) is increasingly used for intracranial artery stenosis-related large vessel occlusion (ICAS-LVO), but optimal patient selection remains uncertain. We investigated the baseline and procedural factors associated with receiving RS and whether they modified the as...

Senescent pulmonary epithelial cells-derived S100A10 drives epithelial-fibroblast crosstalk through inhibiting vimentin ubiquitination in pulmonary fibrosis

Pulmonary fibrosis is a chronic, lethal, and ageing-associated interstitial lung disease of unknown aetiology, involves pulmonary epithelial cell senescence and fibroblast activation. However, the underlying mechanism remains elusive. This study aims to investigate the role and p...

Serial echocardiographic changes in left ventricular size and calculated mass after transcatheter aortic valve replacement for predominant native aortic regurgitation without severe aortic stenosis: a retrospective cohort study

Left ventricular end-diastolic diameter (LVEDD) is widely available but is one-dimensional and load dependent. We evaluated serial LV size and calculated LV mass after TAVR for predominant native aortic regurgitation (AR) without severe aortic stenosis (AS), using all quantitativ...

A case report of rare primary extraosseous Ewing sarcoma of the bladder is presented, with confirmation by pathological, immunohistochemical, and molecular analyses

Extraosseous Ewing sarcoma (EES) of the bladder is an extremely rare, highly aggressive small round cell malignancy. Because its clinical manifestations and imaging features are nonspecific and its histological appearance closely mimics that of other small round cell tumors, misd...

SNX4 promotes glioblastoma progression through the TGFβ1/Smad signaling pathway and represents a potential therapeutic target

Abstract Background Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor that still lacks highly specific and clinically effective molecular targets for GBM treatment. Sorting Nexin 4 (SNX4) is an important regulatory molecule involved in intracellular membrane...

Association between PCSK9 and post-stroke cognitive impairment: a retrospective cohort study and predictive models establishment based on machine learning

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained increasing attention due to its involvement in lipid metabolism and neuroinflammation regulation. High PCSK9 levels are linked to an elevated risk of cerebrovascular events and small vessel diseases. However, system...

Factors associated with early hematoma expansion in intracerebral hemorrhage and the value of non-contrast computed tomography imaging features combined with clinical data for early identification

PURPOSE: Early hematoma expansion (HE) after intracerebral hemorrhage (ICH) critically affects patient outcomes. Identifying HE risk using emergency non-contrast computed tomography (NCCT) features and clinical data is important for early risk stratification and evaluation. This...