First Affiliated Hospital of University of South China

Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer's disease.

Alzheimer’s disease is an inflammatory neurodegenerative disease for which no effective clinical treatment currently exists. We have previously reported that mesenchymal stem cell–derived extracellular vesicles delay retinal degeneration by exerting anti-inflammatory effects thou...

Genome-wide genetic overlap analysis of the genetic contribution shared between stroke and trouble falling asleep, with cross-ethnic validation

Stroke is among the leading causes of death and disability. Trouble falling asleep is a common sleep-related problem. Epidemiological studies show a correlation, but the genetic mechanisms remain unclear. We combined large-scale GWAS summary statistics with clinical cohort data f...

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

ABSTRACT Resistance to second‐generation antiandrogens poses a major therapeutic challenge in castration‐resistant prostate cancer (CRPC). While ferroptosis evasion has been implicated in treatment failure, the key molecular determinants driving this evasive process are poorly un...

Systematic benchmarking of evaluation paradigms, safety boundaries, and clinical reasoning gaps for multimodal large language models in rehabilitation

Abstract Motor rehabilitation and clinical biomechanical assessment rely on expert judgement to evaluate movement quality, pathological compensation, and spatiotemporal motor dynamics. Existing automated approaches mainly depend on conventional computer vision methods, such as sk...

Cardiac fibrosis: mechanistic insights and translational advances

Abstract Cardiac fibrosis is a critical pathological process driving the progression of heart failure, characterized by excessive extracellular matrix deposition, collagen network remodeling, and expansion of the myocardial interstitium. While fibrosis may reflect a reparative re...

Integrated analysis of single-cell and transcriptome data reveals temporal dynamics of microglial phagocytic reprogramming in neuropathic pain progression

Abstract Neuropathic pain (NP) often progresses from acute to chronic, but the mechanisms driving this transition remain unclear. Microglia play a central role in spinal sensitization, yet their functional evolution during pain chronification is poorly understood. Through integra...

Dose-response relationship between metabolic disease burden and myocardial deformation: a confounder-adjusted linear regression analysis

Metabolic diseases are increasingly recognized as contributors to cardiac dysfunction, but the dose–response relationship between metabolic disease burden and myocardial deformation remains unclear. This single-center retrospective study included ST-segment elevation myocardial i...

Multimodal fusion of radiomics, dosiomics and deep learning for predicting radiation-induced hypothyroidism after radiotherapy in nasopharyngeal carcinoma: a multicenter study

To develop and externally validate a prediction framework integrating clinical factors, dose‒volume histogram (DVH) parameters, radiomics, dosiomics and deep - learning (DL) features for individualised radiation-induced hypothyroidism (RIHT) risk assessment. This retrospective mu...

Geriatric nutritional risk index and prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma

To evaluate the prognostic value of the pretreatment Geriatric Nutritional Risk Index (GNRI) in middle-aged and older patients with nasopharyngeal carcinoma (NPC). This study included 235 patients with NPC aged ≥ 50 years. Patients were stratified into low GNRI (GNRI ≤ 98) and hi...

A retrospective study on clinical and survival differences of head and neck versus other second primary malignancies in nasopharyngeal carcinoma survivors

Abstract Background Nasopharyngeal carcinoma (NPC) survivors face elevated risks of second primary malignancies (SPM); however, disparities between head and neck (HN-SPM) and non-head and neck (non-HN-SPM) are incompletely characterized. Methods This retrospective study analyzed...

The TLR9-CXCL2 complex orchestrates mitochondrial DNA-driven regulatory B cell dysfunction in acute lung injury

Acute lung injury (ALI)/Acute respiratory distress syndrome (ARDS) is a lethal condition driven by unresolved inflammation. Circulating mitochondrial DNA (mtDNA) acts as a potent damage-associated molecular pattern, yet its direct role in disrupting adaptive immune checkpoints re...