First Affiliated Hospital of University of South China

Multimodal fusion of radiomics, dosiomics and deep learning for predicting radiation-induced hypothyroidism after radiotherapy in nasopharyngeal carcinoma: a multicenter study

To develop and externally validate a prediction framework integrating clinical factors, dose‒volume histogram (DVH) parameters, radiomics, dosiomics and deep - learning (DL) features for individualised radiation-induced hypothyroidism (RIHT) risk assessment. This retrospective mu...

Geriatric nutritional risk index and prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma

To evaluate the prognostic value of the pretreatment Geriatric Nutritional Risk Index (GNRI) in middle-aged and older patients with nasopharyngeal carcinoma (NPC). This study included 235 patients with NPC aged ≥ 50 years. Patients were stratified into low GNRI (GNRI ≤ 98) and hi...

A retrospective study on clinical and survival differences of head and neck versus other second primary malignancies in nasopharyngeal carcinoma survivors

Abstract Background Nasopharyngeal carcinoma (NPC) survivors face elevated risks of second primary malignancies (SPM); however, disparities between head and neck (HN-SPM) and non-head and neck (non-HN-SPM) are incompletely characterized. Methods This retrospective study analyzed...

The TLR9-CXCL2 complex orchestrates mitochondrial DNA-driven regulatory B cell dysfunction in acute lung injury

Acute lung injury (ALI)/Acute respiratory distress syndrome (ARDS) is a lethal condition driven by unresolved inflammation. Circulating mitochondrial DNA (mtDNA) acts as a potent damage-associated molecular pattern, yet its direct role in disrupting adaptive immune checkpoints re...