First Affiliated Hospital of Sichuan Medical University

Spatiotemporal Dynamics of 2‐methoxy‐4‐vinylphenol Production Driven By Microbial–Environmental Interactions During Zaopei Fermentation of Strong‐Flavor Baijiu

ABSTRACT 2‐Methoxy‐4‐vinylphenol (4‐vg) is a key bioactive phenolic compound that confers flavor complexity and health benefits in strong‐flavor Baijiu (SFB), but its dynamic formation during fermentation remains unclear. In solid‐state heterogeneous fermentation system, material...

Stage-specific nanotherapeutics for glaucoma target elevated IOP, impaired aqueous-humor outflow, RGC degeneration, and fibrotic inflammation during postoperative wound healing

Glaucoma is a chronic neurodegenerative disease in which elevated intraocular pressure (IOP), impaired aqueous-humor outflow, retinal ganglion cell (RGC) degeneration, and postoperative fibrosis may coexist or predominate at different stages. Conventional therapies are effective...

68Ga-FAPI-04 PET/CT has high diagnostic efficacy in Tg-positive and Tg-negative differentiated thyroid cancer

Background Thyroglobulin (Tg) is a standard biomarker for monitoring differentiated thyroid carcinoma (DTC) after radioiodine therapy, yet its reliability is compromised by false-positive and false-negative results. This study aimed to evaluate the diagnostic performance of 68 Ga...

Sodium-glucose cotransporter-2 inhibitors and gastrointestinal neoplasm risk in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Abstract Background The potential carcinogenic effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) remain controversial, particularly regarding site-specific gastrointestinal (GI) neoplasms. This systematic review and meta...

Comparison of three interpretation criteria for [⁶⁸Ga]Ga-DOTATATE PET/CT in suspected pheochromocytoma and paraganglioma of the adrenal gland or retroperitoneal space

Pheochromocytomas and paragangliomas (PPGLs) frequently overexpress somatostatin receptor subtype 2 (SSTR2), making [ 68 Ga]Ga-DOTATATE PET/CT a promising functional imaging modality. However, the optimal interpretation criteria for distinguishing PPGL from non-PPGL lesions in cl...

A portable nanobiosensor with machine learning: enabling multi-cytokines point-of-care testing and early identification of sepsis immunoparalysis

Abstract Sepsis immunoparalysis (SIs) is a major factor contributing to organ dysfunction. However, emergency departments (EDs) and intensive care units (ICUs) currently lack a rapid workflow for early identification of SIs. Herein, an innovative strategy for early SIs identifica...