First Affiliated Hospital of Shihezi University Medical College

Machine Learning in Amyloidogenic Polypeptide Research: From Sequence Prediction to Drug Discovery

Abstract Over the past decade, machine learning (ML) has established a transformative paradigm for investigating amyloidogenic polypeptides. Characterized by their propensity to form ordered, β-sheet-rich fibrillar aggregates, these polypeptides are centrally implicated in the pa...

RCTE: A multi-class object detection framework for dental panoramic radiographs

Background Dental panoramic radiographs play an important role in oral disease screening, computer-aided diagnosis, and clinical treatment planning. However, accurate multi-class detection remains challenging due to small lesion sizes, ambiguous anatomical boundaries, insufficien...

PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells

Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant associated with hyperuricemia. How PFOS affects urate-related responses in human proximal-tubule cells remains incompletely understood. We examined cellular uric acid content and URAT1/GLUT9 protein abundanc...

Quantitative Contrast-Enhanced Ultrasound Characterization of Perilesional Perfusion and Its Association with CD34-Positive Cell Density in a Rat Model of Hepatic Alveolar Echinococcosis

Hepatic alveolar echinococcosis (HAE) is characterized by infiltrative growth and remodeling of perilesional host tissue, including microvascular changes. We investigated whether quantitative contrast-enhanced ultrasound (CEUS) could characterize perilesional perfusion and its an...

Prognostic value of circ_0049271 in NSCLC and its regulatory effect on tumor

To explore the prognostic significance and functional role of circ_0049271 in non-small cell lung cancer (NSCLC). Clinical data were meticulously collected from 140 patients diagnosed with NSCLC. Lung cancer tissues, along with adjacent normal tissues, were preserved at -80 °C. A...

Broad-pedicle posterior tibial artery perforator-plus and sural neurocutaneous flaps as two distally based options for moderate-sized distal lower-leg and ankle defects: a retrospective cohort study

Abstract Background Moderate-sized distal lower-leg and ankle defects can be reconstructed with local flaps when adjacent donor tissue and vascular territories remain intact. We assessed two anatomy-selected, non-interchangeable options: a broad-pedicle posterior tibial artery pe...

Association between the ratio of serum uric acid to high-density lipoprotein cholesterol in early pregnancy and the incidence of gestational diabetes mellitus: a prospective cohort study

To investigate the ratio of uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) (UHR) in early pregnancy and the risk of gestational diabetes mellitus (GDM), and to evaluate its potential predictive value as a risk indicator for early identification of GDM among pregna...

Nasal Brushing Transcriptomics Reveals Candidate Biomarkers of Glucocorticoid Treatment Response in Allergic Rhinitis

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Demographic time bomb in COPD (1990–2050)

Chronic obstructive pulmonary disease (COPD) is a leading global cause of morbidity and mortality, characterized by irreversible airflow limitation and progressive symptoms. Despite declining age-standardized rates (ASRs), absolute burdens are rising due to population aging and g...

Gastritis cystica profunda with early gastric cancer persisting for 9 years in the stage of high-grade intraepithelial neoplasia

Abstract Gastritis cystica profunda (GCP) is a benign lesion characterized by the submucosal proliferation of cystic gastric glands. It most frequently occurs in patients with a history of gastric surgery but is infrequently found in those with an unoperated stomach. While genera...

Advanced lung cancer inflammation index predicts in-hospital mortality and refines risk stratification in patients with cirrhosis

Conventional prognostic scores for liver cirrhosis frequently overlook the nutritional and systemic inflammatory status of patients. The Advanced Lung Cancer Inflammation Index (ALI) is a novel biomarker that integrates these two dimensions. This study aimed to investigate the cl...

Research Progress on Artificial Intelligence-Assisted Dynamic Evaluation of Psoriasis：A narrative review

This narrative review focuses on psoriasis, a chronic recurrent inflammatory skin disease with multisystem comorbidities that significantly impairs patients' quality of life. The recurrent nature of the disease often imposes substantial psychological burden, accompanied by anxiet...