First Affiliated Hospital of Shantou University Medical College

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Local flow patterns determine the uneven distribution of atherosclerotic lesions, yet the underlying mechanism remains poorly defined. We previously reported that protein tyrosine phosphatase nonreceptor type 14 (PTPN14) is implicated in atherosclerosis. Its role in flow-dependen...

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes for regulators of the vascular smooth muscle cell (VSMC) contractile phenotype usi...

Thromboxane A₂ analog U46619 promotes vascular smooth muscle cell apoptosis via Hippo pathway inhibition and its clinical relevance in aortic dissection

Apoptosis of human vascular smooth muscle cells (HAVSMCs) plays a pivotal role in the pathogenesis of aortic dissection (AD). In this study, we first observed in clinical samples that, compared with age- and sex-matched controls, patients with acute Stanford type A AD exhibited s...