First Affiliated Hospital of Jiamusi University

Histone Post-Translational Modifications at the Metabolism–Chromatin Interface: Reprogramming of Neuroinflammation in Alzheimer’s Disease

Increasing evidence implicates histone post-translational modifications in the persistence of neuroinflammation in Alzheimer’s disease (AD), yet how transient pathological insults are converted into sustained immune states remains unclear. In this Review, we examine histone PTMs...

Diffuse bilateral differentiated high-grade thyroid carcinoma presenting as a giant clinical neck mass with iodine-avid pulmonary metastases: a case report and focused literature review

Differentiated high-grade thyroid carcinoma (DHGTC) is a follicular-cell-derived malignancy defined in the 2022 World Health Organization classification. It retains differentiated morphology but shows tumor necrosis and/or at least 5 mitoses per 2 mm². Longitudinal evidence on gi...