First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

The therapeutic effect of genistein on microfracture based on network pharmacology, immune cell abundance analysis and experimental verification

Postmenopausal osteoporosis is a metabolic bone disease mainly attributed to estrogen deficiency. Genistein, a major phytoestrogen, has been reported to exert a direct suppressive effect on osteoclasts. The aim of this study was to explore the possible impact of genistein on oste...

Identification of Kaempferol for Skeletal Muscle Wasting in Cancer Cachexia Through Bibliometric Analysis and Network Pharmacology: Metabolomic and Experimental Evaluation

Cancer cachexia (CC) is a multifactorial syndrome characterized by progressive skeletal muscle wasting, systemic inflammation, and metabolic dysregulation. Traditional Chinese medicine (TCM) contains numerous bioactive compounds with potential multitarget effects, but systematic...

Dual-organelle–coordinated sonodynamic nanoplatform amplifies immunogenic cell death to drive robust antitumor immunity in cold tumors

Immune-excluded “cold” tumors are characterized by dense stromal barriers, limited cytotoxic T-cell infiltration, and insufficient immunogenic cell death (ICD), which collectively restrict the efficacy of immunotherapy. Pancreatic ductal adenocarcinoma (PDAC) and triple-negative...

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate c...