First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

Polygonatum sibiricum polysaccharide attenuates BMSC senescence by inhibiting NCOA4-mediated ferritinophagy

Context BMSC senescence is associated with osteoporosis progression. Polygonatum sibiricum polysaccharide (PSP) shows potential anti-senescence activity, but its effects on bone marrow mesenchymal stem cells (BMSCs) remain unclear.Objective To investigate the protective effects a...

Baihe Zhimu Decoction ameliorates anxious depression via PI3K / AKT / mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

BACKGROUND: Anxious depression involves severe emotional dysregulation with a high risk of relapse and suicide. Although the classical Traditional Chinese Medicine formula Baihe Zhimu Decoction (BZD) is widely used for affective disorders, its underlying mechanisms remain poorly...

Hepatobiliary phase imaging in HCC: revisiting diagnostic algorithms and clinical utility of gadoxetic acid-enhanced MRI across international guidelines

Abstract Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide. In at-risk populations, noninvasive imaging diagnosis relies primarily on the vascular hallmarks of arterial phase hyperenhancement and washout appearance. However, these features...

Tenascin-C Promotes Fibroblast Pathogenic Features and is Associated with Synovial Inflammation in Rheumatoid Arthritis

Despite the recognized involvement of Tenascin-C (TNC), an extracellular matrix glycoprotein induced during chronic inflammation, in tissue remodeling and inflammatory disorders, its clinical significance and functional roles in rheumatoid arthritis (RA) remain incompletely under...

Non-pharmacological interventions for lower limb rehabilitation after stroke: a systematic review and network meta-analysis

Stroke is a leading cause of long-term adult disability, and lower limb dysfunction substantially limits functional independence. This study aimed to systematically compare the effects of different non-pharmacological rehabilitation interventions on lower limb recovery after stro...

Clinical improvement of premature ventricular contraction in an elderly patient treated with Chaihu Sanshen Capsule

Rationale: Premature ventricular contraction (PVC) is one of the most common kinds of arrhythmias for which the treatment poses a therapeutic dilemma. Traditional Chinese medicine has a long history in arrhythmia treatment, and this is a rare case of an elderly patient with PVC w...

Safety of eribulin: A real-world study based on a pharmacovigilance database

Eribulin is used to treat metastatic breast cancer, but its adverse event (AE) profile requires comprehensive analysis using FDA Adverse Event Reporting System (FAERS) data to guide clinical use. We analyzed eribulin-related AE reports in FAERS (Q1 2011 - Q2 2024). Disproportiona...

Joint associations of problematic smartphone use and cyberbullying victimization with depressive and anxiety symptoms among Chinese primary and secondary school students: a large-scale school-based study

Problematic smartphone use (PSU) and cyberbullying victimization (CBV) are independently associated with emotional problems among adolescents. However, whether their co-occurrence is associated with a greater burden of depressive and anxiety symptoms remains unclear. This study e...

Risk factors for sudden cardiac death in heart failure

Background: Heart failure (HF) is a global health burden with high mortality. Sudden cardiac death (SCD) remains a major complication, highlighting the need for accurate risk prediction. Methods: We conducted a systematic review and meta-analysis, guided by the Population, Interv...

The therapeutic effect of genistein on microfracture based on network pharmacology, immune cell abundance analysis and experimental verification

Postmenopausal osteoporosis is a metabolic bone disease mainly attributed to estrogen deficiency. Genistein, a major phytoestrogen, has been reported to exert a direct suppressive effect on osteoclasts. The aim of this study was to explore the possible impact of genistein on oste...

Identification of Kaempferol for Skeletal Muscle Wasting in Cancer Cachexia Through Bibliometric Analysis and Network Pharmacology: Metabolomic and Experimental Evaluation

Cancer cachexia (CC) is a multifactorial syndrome characterized by progressive skeletal muscle wasting, systemic inflammation, and metabolic dysregulation. Traditional Chinese medicine (TCM) contains numerous bioactive compounds with potential multitarget effects, but systematic...

Dual-organelle–coordinated sonodynamic nanoplatform amplifies immunogenic cell death to drive robust antitumor immunity in cold tumors

Immune-excluded “cold” tumors are characterized by dense stromal barriers, limited cytotoxic T-cell infiltration, and insufficient immunogenic cell death (ICD), which collectively restrict the efficacy of immunotherapy. Pancreatic ductal adenocarcinoma (PDAC) and triple-negative...

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate c...