First Affiliated Hospital of Henan University of Traditional Chinese Medicine

Role of PANoptosis in cancer: molecular mechanisms and therapeutic insights

Abnormal cell death plays a crucial role in cancer development. Inducing tumor cell death is an important strategy for cancer treatment. Against this backdrop, with the in-depth study of the regulatory mechanisms of cell death, the discovery of interactions existing among pyropto...

Patient-Reported Outcome scale for Bronchiectasis (BE-PRO): development and validation in China

BACKGROUND: Patient-reported outcomes (PROs) have become essential endpoints in clinical trials for bronchiectasis. However, no validated PRO instrument currently exists for the Chinese population. This study aimed to develop and validate a disease-specific Patient-Reported Outco...

Coaxial Printing Strategy for Fabricating Hydrogel-Based Fiber Sensors with High Flexibility and Consistency

Abstract Hydrogel fibers are of great interest in soft bioelectronics due to their miniature size, high flexibility, and excellent compatibility with biological tissues. However, it remains challenging to maintain structural and sensing performance stability during large-scale fa...

Effects of acupuncture on brain function in patients with depression

Background: Depression poses a major global health burden. Many patients exhibit treatment resistance or experience intolerable side effects with standard therapies. Acupuncture shows promise as an adjunctive therapy for depression, but its neurobiological mechanisms remain incom...

Synchronous ReactiveOxygen Species Scavenging andImmunomodulation for Autoimmune Uveitis Therapy by a MannosylatedBiomimetic Nanocloak

Abstract Autoimmune uveitis is a recurrent, vision-threatening inflammatory disease that demands precise and ongoing treatment. However, current therapies have limitations in ocular targeting, in controlling reactive oxygen species (ROS), and in regulating key inflammatory pathwa...

Asiatic acid alleviates dexamethasone-induced muscle atrophy through regulating the Sirt1/PGC-1α/FOXO3 pathway.

BACKGROUND: Skeletal muscle atrophy, which results in muscular dysfunction and weakness, is associated with various factors, including aging, sepsis, chronic diseases, and long-term glucocorticoid therapy. Although asiatic acid exhibits multiple biological activities and can acti...