First Affiliated Hospital of Henan University of Science and Technology

Joint trajectories and associated characteristics of postpartum depressive and anxiety symptoms: a longitudinal study

Postpartum depressive and anxiety symptoms are common postpartum mental health issues, and these symptoms often co-occur. However, previous studies have primarily analyzed them separately, with limited evidence regarding their joint developmental trajectories and associated chara...

Cell-free RNA in spent embryo medium for non-invasive assessment of preimplantation embryo quality: a review

Embryo quality assessment of preimplantation was a key step that affects the treatment outcomes of assisted reproductive technology (ART). Conventional morphological grading and time-lapse imaging (TLI) were widely used in clinical embryo selection. However, these methods mainly...

Biomechanical analysis of mandibular second molar with varying distal alveolar bone defects: a finite element study with two illustrative clinical cases

The level of alveolar bone distal to the mandibular second molar, following the extraction of the mandibular third molar, may affect the biomechanical performance. This study aimed to analyze the biomechanical performance of the mandibular second molar under different coaptation...

Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial

AIMS: Crisugabalin (HSK16149), a selective γ-aminobutyric acid (GABA) analog, has shown preliminary efficacy in controlling diabetic peripheral neuropathic pain (DPNP), but efficacy in patients with inadequate response to prior pregabalin treatment remains unknown. MATERIALS AND...

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

ABSTRACT Accurate and in situ detection of uracil‐DNA glycosylase (UDG) is crucial for clinical diagnosis and prognosis assessment. However, conventional methods show low accuracy, limited sensitivity, and off‐target signal leakage due to flawed signal input/output and amplificat...

CRISPR-mediated recombinase-assisted amplification for hazard assessment of Vibrio parahaemolyticus on microfluidic system

Highly sensitive and accurate detection of virulence and drug resistance genes in Vibrio parahaemolyticus ( V. parahaemolyticus ) is essential for disease prevention and the control of foodborne transmission. In this research, a novel RAA-CRISPR/Cas12a-based microfluidic hazard a...

Identification of SST as a glioblastoma diagnostic biomarker via integrated bulk and single-cell transcriptomics and DrugReflector AI-driven drug discovery

This study aims to identify reliable diagnostic biomarkers and explore their biological significance in glioblastoma (GBM). The bulk transcriptomic dataset GSE68848 was used for differential expression and weighted gene co-expression network (WGCNA) analyses, and core genes were...

Evaluation of the Anti-Neuroinflammatory Activity of Theophylline Derivatives in Activated Microglia

Abstract ctive: Microglial activation-mediated neuroinflammation is a pivotal pathological hallmark of various neurological disorders. Although theophylline suppresses pro-inflammatory cytokine secretion, and 1,2,3-triazole scaffolds possess intrinsic anti-inflammatory properties...

Bioinspired Surface Enabled by Anisotropic Pyramid Structure Arrays for Directional Liquid Self‐Transport

ABSTRACT Inspired by the phenomenon of directional liquid transport in natural organisms, various bionic surfaces with customized topological structures have been designed and fabricated, contributing to advances in such fields as microfluidics, microreactors, energy harvesting,...

β-Blockers, anxiety, and sleep: an analysis of interactions in early sleep disorders following percutaneous complete revascularization

To investigate the factors influencing sleep quality in the early postoperative period following complete revascularization, focusing on the interaction between anxiety levels and β-blocker use, and to examine whether this interaction is moderated by variables such as insulin res...

Scavenger Receptor Class B Type 1 Mediated Transport Enables Delivery Across Capillarized Liver Sinusoids in Metabolic Dysfunction-Associated Steatohepatitis

Abstract Liver fibrosis in metabolic dysfunction associated steatohepatitis (MASH) lacks effective therapies, in part because therapeutic agents poorly penetrate the capillarized sinusoidal endothelium. As fibrosis progresses, liver sinusoidal endothelial cells (LSECs) become def...

LncRNA GAS6-AS1 promotes ischemic stroke injury through miR-370-3p/TFRC-mediated ferroptosis and disruption of Nrf2/ARE antioxidant responses

Ischemic stroke induces severe neuronal injury after ischemia/reperfusion (I/R), with oxidative disturbance and ferroptotic death emerging as critical contributors. Although GAS6-AS1 has been associated with ischemic stroke progression, the molecular mechanisms underlying its fun...

Integrated multi-omics analysis identifies ELF1 as a B-Cell-associated prognostic biomarker in breast cancer

Breast cancer progression is influenced not only by tumor-intrinsic alterations but also by interactions within the tumor immune microenvironment (TIME). We aimed to identify genetically regulated susceptibility genes associated with immune-related cellular states in breast cance...

Efficacy and Safety of DVDMS ‐Photodynamic Therapy for Dysphagia in Advanced Esophageal Cancer: A Phase II Clinical Trial

ABSTRACT Photodynamic therapy (PDT) is a localized treatment for esophageal stenosis and dysphagia in advanced cancer. This study evaluated the efficacy and safety of Cosiporfin sodium (DVDMS)‐mediated PDT for dysphagia in advanced esophageal cancer. In this Phase II trial, patie...

PANoptosis-related HLTF promotes prostate cancer progression and serves as a potential therapeutic target

Accumulating evidence indicates that pan-apoptosis plays a significant role in tumour progression, highlighting the importance of determining its relevance to tumour prognosis and treatment. This study aims to classify the molecular patterns of pan-apoptosis and explore the molec...

ER stress promoted MAMs formation and ER-Mito Ca2+ transfer: implication for fluoride-induced hippocampal neuronal injury and cognitive deficits in mice.

transfer via the IP3R1/Grp75/VDAC1 complex and provided a potential therapeutic target for the treatment of fluoride-associated neurotoxicity and neurobehavioral disorders.

PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation

The PI3K/AKT signaling pathway serves as a pivotal regulatory hub that governs essential cellular processes, including growth, proliferation, metabolism, survival, and migration. In the context of tumorigenesis and cancer development, aberrant activation of this pathway drives ma...

Determinants of a positive resection margin (R1 status) in esophageal squamous cell carcinoma: a retrospective analysis of 148,121 cases from China

To investigate risk factors for positive proximal and distal resection margins after surgery for esophageal squamous cell carcinoma (ESCC). Total initially enrolled esophageal squamous cell carcinoma patients were 148,121 cases. After strict case screening and quality control, a...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...

ATF7 drives diabetic wound healing via NOTCH1 repression and N1ICD-dependent macrophage polarization control

Chronic, non-healing wounds are a severe diabetic complication. The underlying mechanisms are not fully understood, and the role of ATF7 in this context has not been well characterized. In our study, we utilized db/db diabetic mice and AAV-mediated keratinocyte-specific Atf7 over...