First Affiliated Hospital of Henan University

Patient-Reported Outcome scale for Bronchiectasis (BE-PRO): development and validation in China

BACKGROUND: Patient-reported outcomes (PROs) have become essential endpoints in clinical trials for bronchiectasis. However, no validated PRO instrument currently exists for the Chinese population. This study aimed to develop and validate a disease-specific Patient-Reported Outco...

Coaxial Printing Strategy for Fabricating Hydrogel-Based Fiber Sensors with High Flexibility and Consistency

Abstract Hydrogel fibers are of great interest in soft bioelectronics due to their miniature size, high flexibility, and excellent compatibility with biological tissues. However, it remains challenging to maintain structural and sensing performance stability during large-scale fa...

Effects of Acupuncture on Sleep Quality, Psychological Status, and Neuroendocrine Biomarkers in Patients With Chronic Insomnia: A Systematic Review and Meta-Analysis

Background Chronic insomnia impairs daytime functioning and increases the risk of cardiovascular and psychiatric disorders. Although cognitive behavioral therapy and pharmacotherapy are conventional treatments, their use may be limited by implementation barriers and adverse effec...

Crystal structure of econazole hydronitrate

Abstract C 18 H 16 Cl 3 N 3 O 4 , orthorhombic, Pbca (no. 61), a = 15.1411(9) Å, b = 7.6058(4) Å, c = 35.0896(17) Å, V = 4040.9(4) Å 3 , Z = 8, R gt ( F ) = 0.0544, w R ref ( F 2 ) = 0.1342, T = 296(2) K.

Efficacy of low-level laser therapy for subacromial impingement syndrome: a meta-analysis of randomized controlled trials

To systematically explore the therapeutic effects of low-level laser therapy (LLLT) on pain, shoulder range of motion (ROM), and functional disability in patients with subacromial impingement syndrome (SIS). Eight databases were systematically searched. We assessed study quality...

Prevalence and association of molar-incisor hypomineralisation and dental caries in 7-9-year-old children in Kaifeng, China

The aim of the present cross-sectional study was to analyze the prevalence of Molar-Incisor Hypomineralisation (MIH) and its association with dental caries among 7-9-year-old children in Kaifeng, China. A cross-sectional study was conducted from 2023 to 2025, in which a sample of...

Antidepressant Effects of Lactoferrin-Modified Sodium Alginate-Based Saikosaponin A Nanogels via Intranasal Administration: Involvement of Olfactomedin-Family Proteins

Objective: To develop a lactoferrin-modified sodium alginate nanogel loaded with saikosaponin A (SA-Lf-NG@SAA) and evaluate its potential antidepressant-like effects following intranasal administration. Methods: SA-Lf-NG@SAA nanogels were prepared and optimized using single-facto...

A hybrid memetic algorithm for an energy-aware distributed blocking hybrid flowshop scheduling problem with transportation time

Abstract This study examines the energy-aware distributed blocking hybrid flowshop scheduling problem (DBHFSP-E) considering transportation time. A mathematical programming model is formulated to simultaneously minimize makespan and total energy consumption, and its validity is v...

Berberine Inhibits Eczematous Skin S. aureus-Induced Mast Cell/Basophil Activation and Modulates MAPK-Associated Gene Expression

Staphylococcus aureus (S. aureus), a primary exacerbating factor in eczema, remains a prevalent pathogenic public-health threat. The mechanism of mast cell/basophil degranulation in the context of S. aureus-exacerbated eczema remains unclear. We sought to investigate the direct e...

Computational identification and experimental validation of shared diagnostic biomarkers and gene signatures across HLA-B27-associated immune-mediated diseases

HLA-B27 is strongly associated with a spectrum of immune-mediated diseases, including axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), inflammatory bowel disease (IBD), and acute anterior uveitis (AAU). However, the shared molecular mechanisms and cross-disease diagnos...

Alisol A 23,24-diacetate improves LPS-induced acute lung injury through the IL-17A/NF-κB signaling pathway

Abstract Objective This study utilized the multi-model validation method to confirm that Alisol A 23,24-diacetate (AAD) can improve LPS-induced acute lung injury (ALI) through the IL-17A/NF-κB signaling pathway, providing experimental data support for preclinical research. Method...

Recent Progress in the Synthesis of Sulfonylmethyl Compounds Using Diverse Sulfonylmethylating Reagents

Sulfonylmethyl motif is widely present in many organic compounds and has shown important application in pharmaceutical chemistry, organic synthesis, and materials science. In recent years, considerable attention has been devoted to the development of efficient methods for constru...

LC–MS‐Guided Identification of Bioactive Constituents in Qingfei Jiedu Huatan Formula Reveals Ginsenoside Rb1 as an Endothelial Barrier‐Protective Compound Targeting PAI‐1 in Pneumonia

INTRODUCTION: Qingfei Jiedu Huatan Formula (QJHF) is a traditional Chinese medicine formula developed for severe pneumonia with the syndrome of "phlegm heat obstructing the lung." PURPOSE: This study aimed to investigate the protective effects and underlying mechanisms of QJHF on...

First report of cowpea mild mottle virus naturally infecting Salvia miltiorrhiza in China

Salvia miltiorrhiza Bge, also called Danshen, is a perennial Chinese herbal medicine belonging to the family Lamiaceae and has been used for the treatment of cardiovascular and cerebrovascular diseases (Jung et al. 2020). Henan province is one of the main and genuine production a...

Integrative genomic and functional analyses identify LjbZIP36 as a candidate regulator of β-carotene accumulation during floral color transition in Lonicera japonica

Abstract Background Floral color transition is a characteristic developmental process in Lonicera japonica , during which flowers gradually change from white to golden yellow during flower maturation owing to carotenoid accumulation. Although carotenoid biosynthetic genes have be...

Traditional Chinese Medicine for Chronic Obstructive Pulmonary Disease: Treatment Strategies, Clinical Evidence, and Mechanistic Insights

Chronic obstructive pulmonary disease (COPD) is a prevalent, preventable, and treatable chronic airway disease associated with high morbidity, mortality, and global burden. For this review, we searched PubMed, Web of Science, and major Chinese academic databases for clinical and...

Health economic evaluation of discrete event simulation model for treating chronic obstructive pulmonary disease based on traditional chinese medicine syndrome differentiation

Abstract Objectives To evaluate, from a Chinese healthcare system perspective, the cost-utility of three treatment strategies (Western medicine, Traditional Chinese Medicine [TCM], and combined therapy) for stable chronic obstructive pulmonary disease (COPD) using a discrete even...

Treatment of Acute Ischemic Stroke with Intravenous Urokinase (TASK-UK): Protocol for a Multicenter, Prospective, Real-World Study

Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are both recommended for acute ischemic stroke (AIS) in China. Compared with rt-PA, UK is less expensive and more widely available in clinical practice. The Treatment of Acute Ischem...

Discovery of serum metabolomics characterization in patients with generalized anxiety disorder based on LC-MS

The pressure on people’s lives and work is increasing with the continuous development of modern society, and generalized anxiety disorder (GAD) has become a relatively common psychological problem. Nevertheless, the pathological mechanisms underlying anxiety disorders remain poor...

Combined administration of fructooligosaccharides and Clostridium butyricum attenuates bowel cleansing-induced dysbiosis and safeguards mucosal defense in a murine model

Bowel preparation with polyethylene glycol electrolyte solution (PEG-ELS) is indispensable for gastrointestinal endoscopy and related procedures. However, it disrupts gut microbial homeostasis and increases host vulnerability to ensuing infection. In a murine model, we optimized...