First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Three traditional Chinese patent medicines combined with transarterial chemoembolization for primary liver cancer

Background: To evaluate the objective response rate (ORR) and disease control rate of 3 Chinese herbal medicines (Compound Banmao Capsule, Huaier Granule, and Jinlong Capsule) combined with transarterial chemoembolization (TACE) for primary liver cancer using Bayesian network met...

Cross-sectional associations of insulin resistance-related indices with self-reported anxious days among U.S. adults

Anxiety is a common mental health condition that substantially impairs quality of life. Emerging evidence suggests that insulin resistance may be related to anxiety symptoms. However, the associations between commonly used insulin resistance-related indices and anxiety symptom bu...

Metabolism-Gated Cell Death Switching in Myocardial Ischemia-Reperfusion Injury: From Regulated Death Networks to Precision Cardioprotection

Myocardial ischemia–reperfusion injury (MIRI) is driven by dynamic metabolic disturbances that extend beyond adenosine triphosphate depletion and encompass mitochondrial dysfunction, redox imbalance, calcium overload, iron dysregulation, lipid peroxidation, and inflammatory activ...

Dietary patterns across the continuum of age-related cognitive decline: a scoping review

Cognitive impairment (CI) represents a progressive syndrome along the continuum from subjective cognitive decline (SCD) to dementia, with no curative treatment available. Dietary patterns, as a modifiable factor, have been linked to a slower rate of cognitive deterioration. This...

Evaluating sex as a modifier of cardiomyocyte relaxation in heart failure with preserved ejection fraction: calcium handling, titin, and bioenergetics

Abstract Background Women are disproportionately affected by heart failure with preserved ejection fraction (HFpEF), particularly at older ages, but this epidemiological pattern does not establish sex-modified cardiomyocyte mechanisms. We evaluated whether current evidence suppor...

Secondhand smoke exposure in never-smokers

Chronic kidney disease (CKD) is a major global health burden, yet the association of secondhand smoke (SHS) exposure with CKD among never-smokers remains incompletely characterized. This cross-sectional and prospective cohort study analyzed 13,276 never-smoking adults from the Na...

Targeting Metabolic Pathways to Direct T-Cell Trafficking: Therapeutic Perspectives

Despite advances in immunomodulatory therapies, dysregulated T-cell trafficking persists as a pathological cornerstone in chronic inflammation, autoimmunity, and cancer. This spatially precise navigation—orchestrated by receptor–ligand cascades—ensures immune surveillance but dri...

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis. Clinically, RA manifests as joint pain, swelling, and functional impairment caused by persistent synovial inflammation. Additionally, RA can involve vital organs, inc...

Mitochondrial Homeostasis in Trabecular Meshwork Cells: A Potential Mechanism in Glaucoma

Glaucoma is the second leading cause of blindness worldwide, with its core pathological basis being impaired aqueous humor outflow and elevated intraocular pressure due to trabecular meshwork (TM) dysfunction. The structural and functional stability of the TM largely depends on t...