First Affiliated Hospital of Hebei Medical University

Metabolic-epigenetic nanoregulator attenuates a folate-deficiency-associated senescence phenotype in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is increasingly recognized as an aging-associated disorder driven in part by nucleus pulposus cell (NPC) senescence, yet the nutrient-sensitive metabolic defects that sustain this state remain poorly understood. Here, we investigated impair...

The Role of Eccentric Contraction Training in the Postoperative Rehabilitation of Patients With Total Knee Arthroplasty

ABSTRACT Background Eccentric contraction training may be associated with improved functional recovery after total knee arthroplasty (TKA), but its effects on pain, range of motion, and patient‐reported outcomes during the early postoperative period remain unclear. This randomize...

ZAR1/ZAR2-mediated maternal mRNA fate control in oocyte maturation and early embryonic development

Abstract Oocyte maturation and early embryonic development following fertilization occur during a phase of restricted transcriptional activity and are highly dependent on the storage, translational activation, and timed clearance of maternal mRNAs. In recent years, zygote arrest...

Radiographic outcomes of CT-based robotic-assisted versus manual direct anterior total hip arthroplasty with an acetabular-only registration workflow: a retrospective cohort study

Limited exposure through the direct anterior approach may restrict robotic registration to the acetabulum. We compared postoperative radiographic outcomes of CT-based robotic-assisted DAA THA performed with an acetabular-only bony registration workflow with manual DAA THA. This r...

Active ingredients of Astragalus–ginseng against COPD-associated sarcopenia: network pharmacology and molecular dynamics simulations

Background Chronic obstructive pulmonary disease (COPD)-associated sarcopenia is a critical comorbidity associated with high morbidity and mortality, driven by chronic systemic inflammation, oxidative stress, and proteometabolic dysregulation. The Astragalus membranaceus-Ginseng...

Construction of a nomogram prediction model for opportunistic sarcopenia in patients with malignant tumors.

BACKGROUND AND OBJECTIVES: The aim of this study was to establish a predictive model for opportunistic sarcopenia applicable to Chinese cancer patients, so as to quickly detect the occurrence of this condition and provide a basis for early clinical intervention. METHODS AND STUDY...

Effectiveness of combined nutrition, exercise and psychological interventions in patients with malignancy: A randomized controlled trial.

BACKGROUND AND OBJECTIVES: Patients with malignancy often have a poor prognosis and dismal quality of life. This study aimed to evaluate whether a combined nutrition, exercise, and psychological intervention could improve these outcomes. METHODS AND STUDY DESIGN: In an open-label...