First Affiliated Hospital of Harbin Medical University

Association of serum 25-hydroxyvitamin D and physical frailty with cardiovascular health in US adults

Evidence on the association between cardiovascular health (CVH) and frailty remains limited, and the role of serum 25-hydroxyvitamin D (25(OH)D) in this relationship is not fully understood. This study aimed to examine the association between frailty and CVH and to investigate th...

Multi‐Omics Integration Reveals Metabolic Reprogramming and EMT ‐Driven Metastasis in Triple‐Negative Breast Cancer

ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential and poor prognosis, yet the molecular mechanisms driving metastasis remain incompletely understood. Here, we performed integrated transcriptomic, metabolomic, and imaging mass cy...

Mapping the Tissue Architecture and Endothelial‐ PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

ABSTRACT Hepatic angiomyolipoma (HAML) is a rare variant of perivascular epithelioid cell neoplasms (PEComas). Unlike its more common renal angiomyolipoma (RAML), the unique spatial microenvironment of HAML and its specific progression mechanisms remain poorly characterized. Here...

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

ABSTRACT Traumatic brain injury (TBI) induces brain tissue ischemia, hypoxia, and heightened glycolysis, leading to lactate accumulation. Lactate exerts multiple pathophysiological effects in the aftermath of TBI. This study aimed to elucidate the role of lactate‐mediated lactyla...

Hydrogen gas alleviates osteoarthritis by inhibiting oxidative stress, apoptosis, inflammation, and extracellular matrix catabolism via the Nrf2/HO-1/NOX4 signaling pathway

Osteoarthritis (OA) is a chronic degenerative and debilitating disease. Reactive oxygen species (ROS) and oxidative stress play key roles in OA. NADPH oxidase 4 (NOX4) represents a major ROS source in chondrocytes. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) activa...

The study of selective percutaneous pulmonary artery denervation guided by high-frequency stimulation for monocrotaline-induced porcine pulmonary arterial hypertension

Percutaneous pulmonary artery denervation has recently emerged as a potential therapeutic approach for pulmonary arterial hypertension (PAH). This study aims to investigate the feasibility of selective pulmonary artery denervation guided by high-frequency stimulation mapping. Fif...

Prediction of lymph node metastasis in colorectal cancer based on clinical data, body composition, and radiomics

Abstract Objective To develop and validate a positron emission tomography/computed tomography (PET/CT)-based model integrating clinical variables, body composition indices, and radiomics features for predicting lymph node metastasis (LNM) in colorectal cancer (CRC). Materials and...

Genetic and pharmacological evidence linking CB1R signaling to hippocampal GABAergic dysfunction in ASD mouse model

Autism spectrum disorder (ASD) is a neurodevelopmental disorder increasingly linked to disrupted GABAergic inhibition and altered excitatory-inhibitory balance. Cannabinoid receptor 1 (CB1R), enriched on GABAergic interneurons, modulates inhibitory tone. Whether CB1R dysfunction...

Neoadjuvant therapy and minimally invasive surgery for pancreatic cancer: current evidence and surgical decision-making

Neoadjuvant therapy (NAT) is standard care for borderline resectable and locally advanced pancreatic cancer (PC). While minimally invasive surgery (MIS) is increasingly utilized post-NAT, surgical decision-making and technical feasibility remain debated. This review evaluates cur...

Tripartite motif protein 32 overexpression promotes inflammation and pyroptosis in INS-1 cells via the NF-κB/NLRP3 signaling pathway under high glucose conditions

Abstract Background: Type 2 diabetes mellitus (T2DM) is an inflammatory disease, and the primary features are insulin resistance and β-cell dysfunction. Inflammation and pyroptosis contribute to insulin resistance and β-cell dysfunction. Therefore, it is important to identify nov...

Decreased mechanosensitivity and metabolic reprogramming impair bone regeneration in type II diabetes: core mechanism and targeted scaffold design

Abstract Background Bone regeneration in individuals with type 2 diabetes mellitus (T2DM) is significantly impaired, even when autologous bone grafts are used. However, previous studies have failed to elucidate the physiological mechanism, and effective treatments are lacking. Th...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Oxalate induces phosphatidylserine externalization, apoptosis, and crystal-cell adhesion in renal tubular epithelial cells through the ROS-ADAM17-Notch1 axis

Abstract Background Oxalate salts induce reactive oxygen species (ROS) generation, leading to phosphatidylserine (PS) externalization from renal tubule epithelial cells and the development of kidney stone. This research investigated the roles of ADAM17 (A Disintegrin and Metallop...

RNA-Binding Protein MBNL2 Drives Cardiac Hypertrophy and Dysfunction by Facilitating TPM3 Splicing

BACKGROUND: Cardiac hypertrophy is a major contributor to heart failure development, making its prevention and treatment critical for reducing heart failure–associated mortality. Although alternative splicing is recognized as a key regulatory mechanism in myocardial hypertrophy,...

TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway

Lung adenocarcinoma (LUAD), characterized by its complex molecular heterogeneity and resistance to both conventional and targeted therapies, poses significant therapeutic challenges. Therefore, the identification of novel molecular targets is crucial for enhancing therapeutic str...

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibi...

DMFF: a deep learning-based multi-omics fusion framework for survival prediction and subtype classification in breast cancer

Intra-tumor molecular heterogeneity contributes substantially to survival differences among patients with breast cancer. Although deep learning-based multi-omics integration has shown promise for prognostic modeling, existing approaches may be affected by information leakage duri...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Single‐atom Pt‐N‐C nanozyme targets Rara/Wnt/β‐catenin axis for diabetic cardiomyopathy treatment

Abstract Background and Purpose Diabetic cardiomyopathy (DCM) lacks effective therapies because of complex mechanisms. This study aims to develop a single‐atom nanozyme for integrated antioxidant and signalling regulation in DCM. Experimental Approach A graphene quantum dot‐templ...

Stroke survivors’ health priorities and targeted interventions in home-based post-discharge rehabilitation

<title>Abstract</title> Background This study aimed to describe health problems of the stroke survivors and the corresponding nursing interventions implemented during 12-week home-based post-discharge rehabilitation. Methods This was a descriptive secondary analysis within the co...