First Affiliated Hospital of Guangzhou University of Chinese Medicine

Identification of SGK1 as a candidate regulator associated with myeloid cell senescence in ME/CFS: An integrative transcriptomic and experimental study

Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness lacking objective diagnostic biomarkers and clear pathophysiological understanding. Patients exhibit immune dysregulation and chronic inflammation reminiscent of aging phenotypes, yet the...

Reproductive history and age at natural menopause in US women: a cross-sectional analysis of National Health and Nutrition Examination Survey 1999 to March 2020

Objective: The associations of parity and gravidity with age at natural menopause (ANM) remain incompletely characterized. We examined parity‐ANM and gravidity‐ANM associations and explored non‐live-birth pregnancies descriptively in a nationally representative sample of US women...

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

ABSTRACT Successful pregnancy requires dynamic extracellular matrix (ECM) remodeling at the maternal‐fetal interface, yet whether individual collagen subtypes actively regulate this process remains unknown. Here, collagen type XXIV alpha 1 chain (COL24A1), a uterine‐enriched fibr...

Distribution characteristics and risk factors of hidden blood loss in three posterior minimally invasive spinal fusions: a retrospective study of 158 patients

To investigate the perioperative blood loss distribution and independent risk factors for hidden blood loss (HBL) in three posterior minimally invasive lumbar interbody fusion techniques: minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF), unilateral biportal en...

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72 hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) remains the leading global cause of mortality, with substantial residual inflammatory risk persisting despite statin therapy. We identify a c‐Rel‐driven CD72 hi macrophage subset markedly enriched in human and murine atheros...

Machine learning combined with multidimensional validation identifies SNCA and NR2F2 as key hubs implicated in paraquat and rotenone co-exposure-induced Parkinson’s disease

Combined exposure to pesticides, such as paraquat (PQ) and rotenone (Rot), is a significant risk factor for Parkinson’s disease (PD). However, the synergistic pathogenic mechanisms underlying their co-exposure remain largely elusive. This study aimed to elucidate the key molecula...

High tibial osteotomy for proximal tibial osteonecrosis with medial tibial plateau fracture in a patient with prior knee arthroscopy: a case report

High tibial osteotomy (HTO) is a well-established joint-preserving procedure for unloading the medial compartment of the knee. It has been applied in selected cases of spontaneous osteonecrosis or subchondral insufficiency fracture of the knee. However, the coexistence of proxima...

Mid-to long-term survival analysis following allograft fibular support for Japanese investigation committee type C non-traumatic osteonecrosis of the femoral head: a single-center retrospective cohort study

This study evaluated mid- to long-term femoral-head survival following allograft fibular support (AFS) for Japanese Investigation Committee (JIC) type C non-traumatic osteonecrosis of the femoral head (ONFH) at the pre-collapse or early-collapse stage and examined factors associa...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

Acupuncture Improves Poststroke Cognitive Impairment by Regulating the miR-18a-5p

Background Poststroke cognitive impairment (PSCI) severely impacts patients’ lives. Acupuncture shows potential in improving PSCI, yet the molecular mechanism remains unclear. Aims This study aimed to investigate the potential efficacy of acupuncture in alleviating PSCI symptoms...

Latent profile analysis of benefit finding in maintenance hemodialysis patients and its association with treatment adherence

Abstract Maintenance hemodialysis (MHD) patients experience prominent negative emotions, and dialysis outcomes/prognosis rely heavily on treatment adherence. Few studies have explored the relationship between latent Benefit Finding (BF) categories and adherence. This study aims t...

circBIRC6 regulates cisplatin resistance of choroidal melanoma via positively modulating ERK by sponging miR-503-3p

Abstract Background/AimscircRNA plays a key regulatory role in various human tumors. This study was carried out to investigate the molecular mechanism of circBIRC6 in the regulation of choroidal melanoma cisplatin (DDP) resistance. MethodsThe expression of circBIRC6 in choroidal...

Walking the tightrope: Mixed respiratory failure exacerbated by heart rate control and concurrent pneumonia in an elderly patient with new-onset atrial fibrillation

Rationale: The interplay between new-onset atrial fibrillation (AF), heart failure (HF) with preserved ejection fraction (HFpEF), and acute infection in the elderly presents a complex clinical challenge. Rate control is a cornerstone of AF management, but its application in frail...

Lateral internal sphincterotomy with skin grafting for chronic anal fissure: protocol of a multi-center randomized controlled trial

Abstract Background: Anal fissure, a prevalent anorectal disorder, is defined as a longitudinal tear in the anoderm distal to the dentate line.Chronicity develops in a substantial fraction of anal fissures despite initial conservative success, resulting in significant quality-of-...

Development and multicenter validation of a predictive nomogram for infection risk in patients with multiple myeloma

To explore the key influencing factors of the risk of nosocomial infection in patients with multiple myeloma (MM), to construct a prediction model to effectively assess the risk of infection, and to provide a basis for individualized infection prevention and control. 245 patients...

Severe abdominal aortic calcification is associated with poor two‑year outcomes after posterior lumbar interbody fusion in osteoporotic patients: a retrospective cohort study

To investigate whether preoperative abdominal aortic calcification (AAC) severity assessed on lateral lumbar radiographs is associated with 2year clinical and radiographic outcomes in osteoporotic patients who have undergone posterior lumbar interbody fusion (PLIF) for the treatm...