First Affiliated Hospital of Guangdong Pharmaceutical University

Genetic prioritization and multi-omic characterization of GNS-associated thromboinflammatory signatures in venous thromboembolism

Venous thromboembolism (VTE) remains a major cause of cardiovascular morbidity and mortality. Beyond dysregulated coagulation, accumulating evidence implicates immune and inflammatory pathways in thromboinflammatory susceptibility. However, the genetic determinants of VTE and the...

Latent profile analysis of benefit finding in maintenance hemodialysis patients and its association with treatment adherence

Abstract Maintenance hemodialysis (MHD) patients experience prominent negative emotions, and dialysis outcomes/prognosis rely heavily on treatment adherence. Few studies have explored the relationship between latent Benefit Finding (BF) categories and adherence. This study aims t...

Comparison of non-contrast, non-radiation percutaneous mechanical thrombectomy and catheter-directed thrombolysis in pregnancy-associated iliofemoral deep vein thrombosis: a propensity-matched retrospective cohort study

Iliofemoral deep vein thrombosis (DVT) during pregnancy poses considerable risks to both the mother and the fetus, making it essential to provide prompt, effective, and safe treatment options. Although catheter-directed thrombolysis (CDT) and percutaneous mechanical thrombectomy...

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, activated by cytosolic mitochondrial DNA (mtDNA), has been increasingly implicated in UC. Through p...