First Affiliated Hospital of Guangdong Pharmaceutical University

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, activated by cytosolic mitochondrial DNA (mtDNA), has been increasingly implicated in UC. Through p...