First Affiliated Hospital of Dalian Medical University

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Dental Erosion and Therapeutic Options

Tooth wear is a common, multifactorial non-carious dental hard tissue disease, and it may lead to a range of problems such as hypersensitivity, occlusal dysfunction, and aesthetic defects, significantly impacting patients’ oral health and quality of life. This article aims to sys...

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...

Signal Detection and Temporal Analysis of Aromatase Inhibitor‐Associated Hepatotoxicity: A Pharmacovigilance Study Integrating Bayesian Belief‐Propagation Network and Frequentist Metrics

ABSTRACT Background This study assessed the real‐world hepatotoxicity of third‐generation aromatase inhibitors (AIs) for breast cancer using pharmacovigilance approaches. Methods FAERS data (Q1 2004–Q1 2025) were analysed using a data‐driven disproportionality analysis framework...