First Affiliated Hospital of Dalian Medical University

Tough Hydrogels for Remodeling Ruptured Tendons

Abstract Hydrogels have shown broad application potential due to their high water content and excellent interfacial adaptability, however, conventional biocompatible hydrogels often struggle to simultaneously achieve high strength, high toughness, and favorable biocompatibility,...

Brain-computer interfaces: innovations and challenges in the field of cerebral palsy rehabilitation

Brain-computer interfaces have shown great potential in the rehabilitation of Cerebral palsy, improving the ability of children with cerebral palsy to perform activities of daily living by replacing and restoring lost neurological functions, as well as accurately evaluating cogni...

Emerging roles of long non-coding RNA CASC2 in tumor chemoresistance – a review

Malignant tumors remain a leading cause of global mortality, and the development of chemoresistance represents a major obstacle to effective cancer treatment. Long non-coding RNAs (lncRNAs) are important regulators of tumor progression and therapeutic response. Cancer susceptibil...

The CMPK2–mtDNA axis mediates doxorubicin cardiotoxicity: mechanistic links to STAT1 transcription and FAD-mediated inhibition

Abstract Aims Doxorubicin is a widely used chemotherapeutic agent whose clinical utility is limited by dose-dependent cardiotoxicity. The precise mechanisms bridging mitochondrial dysfunction to cardiac inflammatory responses remain poorly defined. Methods and results We utilized...

Cerebellar α-synucleinopathy contributes to Parkinsonian gait and balance impairment in mouse models

Postural instability and gait difficulty (PIGD) represent a debilitating clinical subtype of Parkinson’s disease (PD) that is largely refractory to dopaminergic replacement therapy. While clinical imaging implies that the cerebellum is involved in these axial deficits, the specif...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

Aqueous extract of Nasturtium officinale: a potential therapeutic approach to be explored in the fight against multidrug-resistant Pseudomonas aeruginosa

The rise in global bacterial resistance has made the development of new therapies an urgent challenge, positioning Pseudomonas aeruginosa as a critical priority pathogen. In this context, phytotherapy stands out due to the wide diversity of bioactive compounds with antimicrobial...

tNGS-guided diagnosis of pulmonary mucormycosis with bacterial coinfection in new-onset diabetes: a case report

Abstract Background Pulmonary mucormycosis is a rapidly progressive and potentially fatal fungal infection, particularly in patients with uncontrolled diabetes. Early diagnosis can be challenging when invasive tissue sampling is high-risk or infeasible. Targeted next-generation s...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Abstract Glioma poses a formidable therapeutic challenge due to its cellular heterogeneity, invasiveness and the protective blood‐brain barrier (BBB). Boron neutron capture therapy represents a promising binary targeted radiotherapy, but its efficacy is hampered by insufficient t...

Coronary Calcification: A Nuanced View

Coronary artery calcification (CAC) is a marker of atherosclerosis. Various quantitative indicators, such as CAC score (CACS) and CAC volume, are associated with the risk of major adverse cardiovascular events (MACE), whereas CAC density has a protective effect. However, the inte...

Association between plaque quantification from coronary CTA and myocardial flow reserve derived from CT myocardial perfusion imaging

Although the relationship between coronary stenosis and myocardial perfusion is well established, the association between quantitative plaque parameters and myocardial perfusion remains poorly understood. This study investigated the association between quantified plaque parameter...

The clinicopathological and molecular characterization in ascites-derived paraffin-embedded cell blocks of ovarian cancer

Abstract This study evaluated immunohistochemical (IHC) markers and homologous recombination repair (HRR) gene mutations in 58 ovarian cancer patients using ascites-derived paraffin-embedded cell blocks. IHC analysis revealed high expression of Pax-8 (87.5–100%), WT-1 (87.8–90%),...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dent...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Dental Erosion and Therapeutic Options

Tooth wear is a common, multifactorial non-carious dental hard tissue disease, and it may lead to a range of problems such as hypersensitivity, occlusal dysfunction, and aesthetic defects, significantly impacting patients’ oral health and quality of life. This article aims to sys...

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...

Signal Detection and Temporal Analysis of Aromatase Inhibitor‐Associated Hepatotoxicity: A Pharmacovigilance Study Integrating Bayesian Belief‐Propagation Network and Frequentist Metrics

ABSTRACT Background This study assessed the real‐world hepatotoxicity of third‐generation aromatase inhibitors (AIs) for breast cancer using pharmacovigilance approaches. Methods FAERS data (Q1 2004–Q1 2025) were analysed using a data‐driven disproportionality analysis framework...