First Affiliated Hospital of Chengdu Medical College

Radioresistance and tumor recurrence: cellular plasticity, tolerant niches, and therapeutic opportunities

Treatment tolerance remains a primary obstacle to successful radiotherapy, frequently leading to adverse patient trajectories. This review integrates evidence on radiation-induced tolerant niches across temporal windows and biological levels. A distinction is drawn between tumor-...

A pH-Responsive Ceria-Supported Iridium Clusterzyme for Combined Antibacterial and Anti-inflammatory Therapies in Diabetic Wound Healing

Abstract The treatment of diabetic wounds is hindered by multiple factors, including Staphylococcus aureus (S. aureus) biofilms (the predominant pathogen in diabetic wound infections), dysregulated immune responses, and insufficient angiogenesis. The complex interactions among th...

Multilevel factors predicting medication adherence among gout patients in China

Adherence to urate-lowering therapy (ULT) is crucial for gout management, yet it remains suboptimal worldwide, particularly in China where relevant data are scarce. This study investigates the prevalence and predictors of medication adherence among Chinese gout patients receiving...

Impact of obstructive sleep apnea syndrome on serum and plasma S100B concentrations: a systematic review and meta-analysis of observational studies with experimental validation

Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is the most prevalent type of sleep apnea. S100B, an astrocyte-derived calcium-binding protein, has been reported to be associated with OSAHS, but the relationship between circulating S100B levels and OSAHS has not been...

ECG theoretical knowledge and interpretation competency of arrhythmias in final-year students: a cross-sectional study

Electrocardiography (ECG) is the key method for diagnosing arrhythmias. Nurses' prompt recognition and early clinical decisions can greatly improve patient outcomes, making it essential to develop nursing students' ECG interpretation skills for arrhythmias. This study aims to ass...

Efficacy and safety of five femtosecond laser platforms in cataract surgery: a network meta-analysis informing platform-specific clinical decision-making

Abstract Background To compare the efficacy and safety of five femtosecond laser platforms (FLPs) in femtosecond laser-assisted cataract surgery (FLACS) and guide clinical selection. Methods Systematic searches (PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov...

Gender-Role Identity as Moderators Between Class Environment and Aggressive Behaviors Among Chinese Children

School violence is a major global public health issue that has received increased scrutiny in recent times. Prior studies have indicated that variations in aggressive behaviors among students are associated with factors such as gender-role identity and class atmosphere. However,...

Risk factors for surgical site infection after internal fixation for thoracolumbar fractures

The purpose of this study was to investigate the risk factors for surgical site infection (SSI) after internal fixation by posterior approach in patients with thoracolumbar fractures. According to whether SSI occurred after internal fixation, patients were divided into SSI group...

Multimodal nanomedicine for precision colorectal cancer management: integrated diagnosis, targeted therapy, and personalized theranostics

Colorectal cancer (CRC) imposes a substantial health burden because of its high incidence and mortality. Despite advances in surgical procedures, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the overall efficacy is still unsatisfactory, especially for advanced...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

The Association Between Metabolic Score for Insulin Resistance and the Risk of Hypertension

Abstract Objectives To systematically investigate the association and dose-response relationship between the metabolic score for insulin resistance (METS-IR) and the risk of hypertension, using data from a prospective cohort study of Chinese adults. Methods A total of 4866 adults...

Comparative Analysis of Clinical Manifestations of Gasless Endoscopic Surgery via Transaxillary and Subclavicular Approaches in Unilateral cN0 Thyroid Cancer

AIM: To compare the clinical efficacy and safety of gasless endoscopic radical thyroidectomy via the transaxillary approach versus the subclavicular approach for unilateral cN0 thyroid cancer.METHODS: A total of 415 patients with unilateral cN0 thyroid cancer admitted between Jan...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

Association Between Psoriasis and Overactive Bladder Among US Adults: A Study Based on 2005–2006 and 2009–2014 National Health and Nutrition Examination Survey

BACKGROUND: Both psoriasis and overactive bladder (OAB) are considered systemic conditions that share many inflammatory or immune pathways in the pathogenesis. One previous study found patients with psoriatic arthritis (PsA) reported significantly higher bladder autonomic dysfunc...

Retrospective analysis of postoperative complications and risk factors in middle ear surgery

Background Postoperative complications following middle ear surgery present ongoing challenges despite advances in surgical techniques. A comprehensive analysis of complication patterns, associated risk factors, and their interactions with patient comorbidities is needed to impro...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...