Fifth Affiliated Hospital of Zhengzhou University

Protein 4.1 R Suppresses Melanoma Progression by Inhibiting Glycolysis via the PI3K/AKT/mTOR Pathway

ABSTRACT Melanoma is a highly aggressive malignancy with strong metastatic potential. Protein 4.1 R, encoded by EPB41 , is a membrane cytoskeleton protein that plays an essential role in maintaining plasma membrane stability and cytoskeletal organization. Recent studies have indi...

Effects of Acupuncture on Sleep Quality, Psychological Status, and Neuroendocrine Biomarkers in Patients With Chronic Insomnia: A Systematic Review and Meta-Analysis

Background Chronic insomnia impairs daytime functioning and increases the risk of cardiovascular and psychiatric disorders. Although cognitive behavioral therapy and pharmacotherapy are conventional treatments, their use may be limited by implementation barriers and adverse effec...

β‐ TP For Diagnosing CSF Leak After the Endoscopic Endonasal Approach Surgery for Sellar Tumors

ABSTRACT Objectives This study aimed to evaluate the diagnostic utility of quantitative beta‐trace protein (β‐TP) as an early biomarker for identifying postoperative cerebrospinal fluid (CSF) leaks following endoscopic endonasal approach (EEA) surgery for sellar tumors. Methods A...

Application of targeted next-generation sequencing in bronchoalveolar lavage fluid testing for pathogen identification in pulmonary infections

Pulmonary infections remain a leading cause of morbidity and mortality worldwide. However, conventional microbiological tests (CMTs) frequently fail to identify the causative pathogens, owing to their limited sensitivity, prolonged turnaround times, and inherent inability to dete...

Motivational orientation and influencing factors of older adults with chronic obstructive pulmonary disease in community dwellings: a latent profile analysis

Chronic obstructive pulmonary disease (COPD) poses a serious threat to older adults’ health. Promoting the adoption of health behaviors among community-dwelling patients is essential for improving prognosis, with motivational orientation serving as a key determinant of health beh...

Network analysis of smartphone addiction, attentional control, and learning adaptation among nursing undergraduates

In the digital learning environment, learning adaptation and attentional control have been shown to be important factors associated with academic success among nursing undergraduates. Smartphone addiction has been associated with impaired attentional control and poorer learning o...