FHNW University of Applied Sciences and Arts Northwestern Switzerland

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

ABSTRACT Biotherapeutics are required to achieve high remission rates in patients with severe ulcerative colitis (UC); however, adverse effects, complex dosing regimens, administration routes, and low patient compliance limit their widespread clinical use. Given the localized nat...

Selection of Suitable Detection Methods for Microplastics in Soil—A Decision-Making Flowchart

The increasing occurrence of microplastics in environmental compartments such as water, soil, air, and food represents a growing challenge for environmental science and policy. Despite their ecological relevance, the reliable detection and quantification of microplastics are hamp...

Creating an Ear and Hearing Health Culture for Professional Ear Users: Current Perspectives on Challenges, Management, and Recommendations

Professional ear users (PEUs), including musicians, instrument makers, or sound engineers, depend on highly trained auditory abilities for occupational performance. Given these demands, PEUs may benefit from tailored prevention, diagnostics, and treatment. Ear and hearing disorde...

Can Intraoperative Therapeutic Window Data Predict Chronic Contact Selection in Deep Brain Stimulation?

Abstract Deep brain stimulation (DBS) programming relies on selecting electrode contacts that maximize clinical benefit while minimizing side effects. The therapeutic window (range of current yielding symptom improvement without adverse effects) is a key criterion in this decisio...

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

A widely tunable femtosecond light source based on green-pumped BBO optical parametric oscillator

Femtosecond lasers in the 700–1000 nm spectral region hold irreplaceable research value in many frontier fields. In this work, to achieve tunable femtosecond laser output in the target spectral region, we first frequency-double a high-power Yb-doped all-fiber femtosecond laser at...

Techno-economic and life cycle assessment of a tandem CO2 and plastic waste-to-fuels system

The transition towards a circular and low-carbon economy requires integrated solutions that enable the simultaneous valorization of waste streams and carbon dioxide. In this context, this study investigates a tandem system combining an electrochemical reactor (PV-EC) and a photo-...

Towards a sustainable astronomical data infrastructure: Optimising linking data from the Rucio datalake to the users areas within the SKA Regional Centres Network

<ns5:p>The distributed architecture of the SKA Regional Centre Network (SRCNet) aims to provide scientific communities worldwide with efficient computational and storage resources to exploit the massive data volumes produced by the SKA Observatory (SKAO). Given the amount of SKAO...

Towards evaluating the effects of visualization and task types on urban planning decisions

Abstract. This study compares visualization types, i.e., 3D, 2D, Oblique 3D, and Combined 2D+3D, coupled in a pairwise fashion for different tasks and scenarios, and investigates their influence on decision-making across selected urban planning tasks. Specifically, we study site...