Ferris State University

Refining genetic circuit design for enhanced type II polyketide biosynthesis in Escherichia coli

Polyketides represent a broad class of structurally diverse natural products with potent antibacterial and anticancer activities. Type II polyketide synthases (T2PKS) are multi-subunit complexes responsible for condensing acylated intermediates, including acetyl-CoA and malonyl-C...

Regulation of PCSK9 During Oxidized LDL-Induced Foam Cell Formation in RAW264.7 Cells

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is traditionally known for regulating plasma LDL cholesterol levels via LDL receptor degradation. This exploratory study examined the association between chemically induced changes in Krüppel-like factor 2 (KLF2), a vasoprotec...