Federico Villarreal National University

Synthesis, DFT studies, and molecular docking of novel pyrazole semicarbazones targeting GPb, PPA-II, and DPP-4 enzymes

Abstract Six new phenyl-1 H -pyrazole-carbaldehyde semicarbazone derivatives ( 1 – 6 ) have been synthesized and characterized by FT-IR, NMR ( 1 H and 13 C), and mass spectrometry. NMR analysis indicated that these compounds in DMSO-d 6 exhibit a cisE isomeric form. This evidence...

Cerebrospinal fluid cytochemical analysis from COVID-19 patients with neurological disorders

Background The COVID-19 pandemic caused by SARS-CoV-2 has affected millions of people worldwide. Most cytochemical studies of cerebrospinal fluid (CSF) in SARS-CoV-2-infected patients show abnormal results. We aimed to determine the physical, cytological, and chemical alterations...

Cost–Accuracy Trade-Offs in Unpaved Rural Road Condition Assessment: Visual Indices and Smartphone-Based IRI in the Ecuadorian Andes

More than 90% of the road network of Loja, Ecuador, is unpaved and lacks an official condition metric. Low-cost measures relate to the IRI on pavements, but not demonstrably on unpaved roads. A 15 km Andean corridor was surveyed in one dry season with four visual–manual indices (...