Federal Office for Radiation Protection

Estimation of global population-weighted annual eye lens dose from cosmic ray exposure.

This study presents the application of an analytical model, PARMA, to estimate the population-weighted annual absorbed dose to the lens of the eye due to cosmic rays. Cosmic ray flux data incorporating geographical altitude, together with the global population data from 2020, wer...

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals

Abstract DNA double-strand breaks (DSBs) which arise in G1- or G0-phase normal human cells are repaired by non-homologous end-joining (NHEJ), a pathway which is important for cell survival but can cause mutations at the break sites. DSB repair by NHEJ is very efficient at high da...

Range of dose enhancement factor for gold nanoparticles in radiotherapy using Monte Carlo simulations

Abstract Gold nanoparticles (GNPs) have been widely investigated as radiosensitizers in preclinical radiotherapy studies and are now advancing into clinical trials. To enhance tumour targeting, various molecular vectors are conjugated with GNPs. The localized radiation energy dep...