Federal Almazov North-West Medical Research Centre

Titin Serum Level Is Elevated in Patients with Myocarditis Depending on Their Genetic Background

Background: The molecular basis of myocarditis is often associated with genetic cardiomyopathies and truncating or loss-of-function variants in the titin gene (TTNtv/lof). Here, we hypothesize that titin serum levels increase in patients with myocarditis, and that this can depend...

Aquatic Microfungi of the Greenland Sea in the Vicinity of Barentsburg Settlement (Svalbard)

Abstract Polar ecosystems are extremely sensitive to anthropogenic impact, which is particularly evident near Arctic settlements with high economic activity. Samples for analysis were collected in 2018–2019 in Grønfjorden (Greenland Sea, Svalbard Archipelago). A comparative study...

Early outcomes of controllable pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension: a single-centre experience at the Almazov National Medical Research Centre

Objective. To evaluate the early outcomes of original controllable pulmonary thromboendarterectomy (PEA) in the treatment of CTEPH. Material and methods. A single-center cohort retrospective-prospective study enrolled 74 CTEPH patients who underwent PEA between 2018 and 2024. All...

Floating right atrial mass in a patient with suspected chronic thromboembolic pulmonary hypertension

Chronic thromboembolic pulmonary hypertension (CTEPH) is a late complication of acute pulmonary embolism (PE), characterized by persistent elevation of pulmonary artery pressure and pulmonary vascular resistance due to narrowing and/or obstruction of pulmonary arteries. In some c...

On a model of cisplatin-induced ototoxicity in Wistar rats

An experimental in vivo model of cisplatin-induced ototoxicity (CO) is a prerequisite for developing methods to prevent hearing loss resulting from cisplatin (CP) chemotherapy. However, there are no clear guidelines regarding its design in a research model as widely used as the W...

Clinical utility of pulmonary artery catheter derived hemodynamic parameters: a prospective clinical study

Background. Induction of anesthesia and mechanical ventilation frequently lead to arterial hypotension whose nature can be elucidated through analysis of volumetric and pressure-derived hemodynamic parameters. These include measured or calculated, including indexed, indicators of...

Methodology for assessing sleep quality and its parameters in the context of neurophysiological and behavioral aspects

Sleep is a fundamental physiological process essential for maintaining cognitive function, emotional stability, and overall health. This paper reviews various parameters influencing sleep quality, including total sleep duration, sleep latency, continuity and stability (restfulnes...

Results of the scientific and practical conference with international participation «Neurology of the XXI Century: Current Issues, Achievements and Innovations». March 26—27, 2026, St. Petersburg

This article presents the findings from the fifth scientific and practical conference with international participation entitled «Neurology of the XXI Century: Current Issues, Achievements and Innovations,» held on March 26—27, 2026, in St. Petersburg. The scientific program inclu...

Beyond majority voting: a new framework for evaluating AI diagnostic systems against expert consensus

The integration of artificial intelligence (AI) into medical diagnostic workflows requires robust and consistent evaluation methods to ensure reliability, clinical relevance, and the inherent variability in expert judgments. Traditional metrics like precision and recall often fai...