Fatima Jinnah Medical University

Efficacy and Safety of Cisplatin Versus Carboplatin for Patients With Squamous Cell Carcinoma of Head and Neck: A Systematic Review and Meta‐Analysis

ABSTRACT Background Cisplatin‐ and carboplatin‐based regimens are widely used in the treatment of head and neck squamous cell carcinoma (HNSCC), yet comparative evidence on survival and toxicity outcomes remains limited. While cisplatin is standard in many settings, carboplatin i...

Myocardial Fibrosis in Pediatric Heart Disease

Myocardial fibrosis is increasingly recognized as a central determinant of adverse cardiac remodeling and long-term cardiovascular outcomes in children with congenital and acquired heart disease. Once considered an irreversible consequence of chronic myocardial injury, fibrosis i...

Left Atrial Myopathy as a Phenotypic Axis in HFpEF: Implications for Pulmonary Hypertension, Exercise Intolerance, and Targeted Therapy

Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome characterized by impaired ventricular relaxation, systemic inflammation, and multisystem cardiovascular dysfunction. Despite growing recognition of HFpEF as a major global health burden, eff...

Mixed phenotype acute leukemia mimicking adult-onset Still’s disease in a pregnant female: A rare case report

Introduction: Mixed phenotype acute leukemia (MPAL) is an uncommon hematologic malignancy characterized by the coexistence of lymphoid and myeloid lineage markers. Although adult-onset Still’s disease (AOSD) is a diagnosis of exclusion, MPAL may rarely present with similar labora...