Far Eastern Memorial Hospital

Soluble N-terminal EphA2 fragment as a diagnostic biomarker and functional mediator of tumor progression in triple-negative breast cancer

Triple-negative breast cancer (TNBC) lacks reliable biomarkers for early detection and remains a highly aggressive disease. Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase frequently overexpressed in advanced cancers, undergoes MMP14-mediated cleavage that releases s...

Diagnosis of tuberculous lymphadenopathy: the role of droplet digital PCR

Background: Tuberculous lymphadenopathy (TB-LAP) is the most common form of extrapulmonary TB and remains diagnostically challenging due to its paucibacillary nature. We evaluated the diagnostic performance of droplet digital PCR (ddPCR) for detecting Mycobacterium tuberculosis (...

Clinical Outcomes of Combined Uvulopalatopharyngoplasty and All-Suture Anchor Tongue Base Suspension for Obstructive Sleep Apnea

Background and Objectives: All-suture anchor tongue base suspension (TBS) is a recently introduced approach that provides mandibular fixation without a permanent metallic anchor body. Clinical outcome data for this technique when incorporated into multilevel surgery remain limite...

Young minds in distress: Exploring the global rise in youth mental health diagnoses

Adolescence represents a critical neurobiological period marked by a developmental “mismatch” between early-maturing limbic systems and the later-maturing prefrontal cortex, conferring heightened vulnerability to the onset of psychiatric disorders. This review synthesizes global...

Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are vulnerable to infections. While sodium-glucose cotransporter-2 (SGLT-2) inhibitors provide established cardiorenal benefits, their effects on infection remain unclear. This study aimed to evaluat...

Association Between Bladder Management Strategies and Symptomatic Urinary Tract Infections in Patients with Chronic Spinal Cord Injury: Lessons from a 5-Year Longitudinal Cohort

Background: Urinary tract infections (UTIs) are a leading cause of morbidity in patients with chronic spinal cord injury (SCI). This study examined the incidence of first and recurrent symptomatic UTIs in patients with chronic SCI and explored clinical factors associated with inf...

Association of low calf circumference and underweight with sarcopenia in older adults with chronic kidney disease: a cross-sectional study

Objectives This community-based, cross-sectional study aimed to evaluate the association of calf circumference and body mass index (BMI) with sarcopenia in older adults with chronic kidney disease (CKD).Methods: Community-dwelling adults aged ≥60 years were enrolled in New Taipei...

Optimizing Recovery in Head and Neck Surgery: Factors Influencing Drainage and Early Discharge

Background: Postoperative bleeding and prolonged drainage after head and neck surgery may delay drainage tube removal and hospital discharge, increasing complication risk and resource utilization. Optimizing intra and postoperative hemostasis is essential to facilitate early reco...

Diabetes mellitus and risk of injury requiring medical care: a nationwide population-based matched cohort study in Taiwan

Abstract Background Diabetes mellitus (DM) is associated with multiple microvascular and macrovascular complications; however, its association with clinically significant injury requiring medical care remains incompletely understood. This study aimed to investigate the associatio...

A Novel Hemizygous CDX4 Missense Variant Identified in a Taiwanese Man with Severe Teratozoospermia

Background and Objectives: Male factors account for approximately 30–50% of subfertile couples. Teratozoospermia is one of the major causes of male infertility; however, the genetic factors underlying many cases remain incompletely understood. This study aimed to identify potenti...

Toward on-premises RAG pipelines for AI-assisted neuroradiology: practical considerations on privacy, accuracy, and timeliness

Accurate differential diagnosis (DDx) in neuroradiology is challenging and remains vulnerable to cognitive biases and inter-reader variability in clinical practice. Despite expert training, human-generated DDx may be limited in breadth. Large language models (LLMs) have shown pro...