Fairview School District

Biologically informed TCR representations improve in-distribution prediction but fail to generalize to unseen epitopes

Background. TCR specificity predictors work on epitopes seen in training and fail on unseen ones. One explanation holds that receptor representations ignore the organization created by V(D)J recombination. We tested it. Methods. From 121,467 deduplicated human TCRβ clonotypes in...

Biologically informed TCR representations improve in-distribution prediction but fail to generalize to unseen epitopes

Background. TCR specificity predictors work on epitopes seen in training and fail on unseen ones. One explanation holds that receptor representations ignore the organization created by V(D)J recombination. We tested it. Methods. From 121,467 deduplicated human TCRβ clonotypes in...