Faculdade de Medicina do ABC

The cost of intensification in high-risk non–muscle-invasive bladder cancer

Non–muscle-invasive bladder cancer (NMIBC) is a common and costly disease that requires experienced teams and adequate infrastructure for its management. Although characterized by high rates of recurrence, a subset of patients also faces a substantial risk of progression to muscl...

Impact of excessive weight gain and pre-gestational obesity on maternal and neonatal outcomes

Excessive gestational weight gain and prepregnancy obesity have been associated with adverse maternal and neonatal outcomes, although their associations with specific pregnancy outcomes may differ. This retrospective, cross-sectional study included 972 women who delivered at a pu...

Correlation between Sperm DNA Fragmentation and Motility Pa-rameters: A Comprehensive Study.

OBJECTIVE: To investigate the relationship between sperm DNA fragmentation (SDF) and sperm motility pa-rameters in men undergoing fertility evaluation. METHODS: This retrospective observational study in-cluded 589 men aged 18-50 years evaluated at a sin-gle Brazilian andrology ce...

Cognitive Functional Therapy for Plantar Heel Pain: A Case Series

BACKGROUND: Plantar heel pain is a prevalent musculoskeletal condition frequently associated with persistent pain, disability, and biopsychosocial contributors. Although guideline-based care has evolved, management often remains centered on passive and tissue-focused strategies,...

Minimally Invasive vs Open Surgery for the Treatment of Spinal Spondylodiscitis: A Systematic Review and Meta-Analysis

Background Despite common conservative management for spondylodiscitis, surgical intervention is indicated in specific clinical scenarios. While open techniques are traditionally favored, the role and efficacy of minimally invasive surgery (MIS) vs conventional open approaches re...

Do Preoperative Glucagon-Like Peptide-1 Receptor Agonists Influence Lumbar Fusion Outcomes? A Systematic Review and Meta-Analysis

Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in patients with obesity and type 2 diabetes, but lumbar fusion-specific associations with postoperative outcomes remain uncertain. Objective To evaluate the association between preoperative GLP...

Are Selenium Status and Inflammation Linked to Cardiometabolic Risk Factors in Inborn Errors of Immunity?

Background/Objective: Patients with Inborn Errors of Immunity (IEI) are at increased cardiometabolic risk due to inflammation, immune dysfunction, and oxidative stress. Given selenium’s essential role in antioxidant defense, this study evaluated plasma selenium concentration in i...

Noninvasive or minimally invasive neuromodulation in animal models of acute ischemic stroke: A systematic review and meta‐analysis

Abstract Background Neuromodulation therapy has emerged as a potential brain cytoprotective strategy in the hyperacute phase of ischemic stroke (IS). This systematic review aimed to evaluate the cytoprotective effects of neuromodulation in animal models of IS. Methods A systemati...

Differential Temporal Changes in Cerebrovascular Hospitalizations During the COVID-19 Pandemic: An Ecological Time-Series Study in the Municipality of São Paulo, Brazil

Background: The COVID-19 pandemic simultaneously affected vascular risk and healthcare utilization. We evaluated whether monthly trajectories of Brazilian Unified Health System (Sistema Único de Saúde; SUS)-financed hospitalizations for different cerebrovascular categories change...

Albumin Precoating of Nanoparticles: A Reliable StealthStrategy?

Abstract Albumin precoating has emerged as a strategy to impart nanoparticles (NPs) with stealth-like properties and as an alternative to NP surface PEGylation. Yet how such coatings influence protein corona formation and hemocompatibility in human blood remains poorly understood...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...

Comparative Study of Myocutaneous Latissimus Dorsi Flap Breast Reconstruction With Implant Versus Lipofilling: Complication Rates and Risk Factors

BACKGROUND: Breast cancer is the most prevalent malignancy among women globally, and mastectomy often forms a critical part of its treatment. Breast reconstruction is an important aspect of post-mastectomy care, contributing to improved psychological well-being and quality of lif...