Faculdade de Ciências Médicas da Santa Casa de São Paulo

Dissociation Between Instrumented Mobility and Self-Reported Function in Adults Aged 70 Years or Older After Unilateral Total Knee Arthroplasty: A Preliminary Longitudinal Study Using an Inertial Sensor and the WOMAC

Background and Objectives: Total knee arthroplasty (TKA) reliably reduces pain and improves self-reported function, yet objective mobility may remain impaired in older adults. We examined the relationship between inertial-sensor-based mobility and the Western Ontario and McMaster...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Provox Life HMEs for Pulmonary Rehabilitation in HME ‐Naïve Laryngectomy Patients: A Randomized Controlled Trial

ABSTRACT Objective To evaluate whether Provox Life Heat and Moisture Exchangers (HMEs) and attachments enable HME‐naïve laryngectomized patients to establish a 24‐h HME routine, and whether the resulting effect on pulmonary symptoms is sustained over 9 months, compared with stand...

Is there an interaction between hypertension and proteinuria in pediatric chronic kidney disease progression? Evidence from the SP-CKD-Kids cohort

Abstract Background Hypertension and proteinuria are established risk factors for chronic kidney disease (CKD) progression in children. Given their pathophysiological interrelationship, whether their coexistence produces a multiplicative interaction remains uncertain. We evaluate...

Are Selenium Status and Inflammation Linked to Cardiometabolic Risk Factors in Inborn Errors of Immunity?

Background/Objective: Patients with Inborn Errors of Immunity (IEI) are at increased cardiometabolic risk due to inflammation, immune dysfunction, and oxidative stress. Given selenium’s essential role in antioxidant defense, this study evaluated plasma selenium concentration in i...

The Transition of Youth With Diabetes From Pediatric to Adult Diabetes Care Services: A Consensus Report of the Joint Working Group of the International Society for Pediatric and Adolescent Diabetes (ISPAD), the European Association for the Study of Diabetes (EASD), and the American Diabetes Association (ADA)

Young adulthood is a period of significant and unique physiological, psychological, sexual, and social upheaval. Related challenges can have an impact on effective diabetes self-management, with high rates of unplanned health care use recorded for many, and consequent increases i...

Low-Intensity Distortion Product Otoacoustic Emission Protocols in Infants and Young Children: Contributions of Age-Specific Ear Characteristics

Purpose: Despite almost complete cochlear maturity at birth, distortion product otoacoustic emission (DPOAE) levels in neonates and infants are typically higher than those measured in older children and adults, depending on the type and frequency stimulus, which suggests function...

Disseminated paracoccidioidomycosis in a black lion tamarin (Leontopithecus chrysopygus) confirmed by histopathology, molecular diagnostics and phylogenetic analysis of DNA from FFPE tissues

Abstract Background Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America, primarily affecting humans. Reports in non-human primates are rare and provide valuable insight into the environmental circulation of Paracoccidioides spp. and the interface between a...

Comparative Study of Myocutaneous Latissimus Dorsi Flap Breast Reconstruction With Implant Versus Lipofilling: Complication Rates and Risk Factors

BACKGROUND: Breast cancer is the most prevalent malignancy among women globally, and mastectomy often forms a critical part of its treatment. Breast reconstruction is an important aspect of post-mastectomy care, contributing to improved psychological well-being and quality of lif...