Ezhou Central Hospital

OTOF Promotes Clear Cell Renal Cell Carcinoma Progression and Angiogenesis Through AKT-Dependent HIF/VEGFA Signaling

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by marked molecular heterogeneity, aggressive clinical behavior, and prominent angiogenesis, highlighting the need to better understand the functional regulators underlying tumor progression and vascular remodel...

Environmental pollutant UV-328 exacerbates chronic colitis and is associated with altered cholesterol metabolism

Environmental exposure is increasingly recognized as an important contributor to the onset and progression of inflammatory bowel disease (IBD). Although the benzotriazole ultraviolet stabilizer UV-328 is widely present in environmental matrixes and biological samples, and exhibit...