Eye & ENT Hospital of Fudan University

MRI‑based radiomics nomogram for distinguishing malignant tumor from benign ones in the orbit: a two‑center study

Accurate differentiation between malignant and benign orbital tumors is essential for clinical decision-making and treatment planning. MRI-based radiomics, which extracts high-dimensional quantitative features from medical images, has emerged as a promising noninvasive approach f...

Risk factors of anterior capsular contraction syndrome in Marfan syndrome after intraocular lens and modified capsular tension ring implantation

Purpose To identify risk factors for anterior capsular contraction syndrome (ACCS) after in-the-bag intraocular lens (IOL) implantation in patients with Marfan syndrome (MFS) and ectopia lentis (EL). Methods This study included patients diagnosed with MFS and EL, who underwent in...

Combined Accommodation and Fusional Training Paradigm Versus Prism Correction for Small-Angle Acute Acquired Comitant Esotropia: A Cohort Study

This study explored 6-month ocular alignment and visual function outcomes associated with a combined accommodative and fusional training paradigm and compared them with outcomes observed after prism correction in patients with small-angle acute acquired comitant esotropia. This p...

Nasopharyngeal Angiofibroma in Adults: Age-Stratified Stage Distribution, Clinical Outcomes, and Exploratory Tumor–Normal Genomics

Background/Objectives: Nasopharyngeal angiofibroma (NA) is generally benign, but recurrent disease and rare malignant transformation remain clinically relevant beyond adolescence. We examined adult clinical presentations, records of malignant transformation, and age-related diffe...

Rotational stability and visual outcomes of toric implantable collamer lenses in eyes with horizontal and non-horizontal implanting orientation: an observational study

PURPOSE: To evaluate the short-term rotational stability and visual outcomes of the toric intraocular collamer lens (TICL) with horizontal and non-horizontal implantation orientation based on the Callisto eye system. METHODS: This observational study analyzed 77 eyes from 51 pati...

Chil4 regulates basal cell activation and neuronal differentiation in olfactory epithelium regeneration

The mammalian olfactory epithelium (OE) exhibits remarkable capacity for continuous regeneration. Our previous work demonstrated that Chitinase-like 4 (Chil4) regulated regeneration in the injured OE. Expanding upon these findings, here we reported that Chil4 deficiency resulted...

Charting the Phenotypic Landscape of FBN1 Variants in Marfan Syndrome With Ectopia Lentis Through Extreme Phenotype Sampling

Purpose: Phenotypic heterogeneity is a hallmark of Marfan syndrome (MFS) with ectopia lentis (EL), yet genotype-phenotype correlations for ocular traits remain incompletely understood. This study aimed to identify genomic determinants of extreme ocular phenotypes using a combined...

Transcriptomic analyses identify TMPRSS4 as a shared biomarker in asthma and atopic dermatitis

Asthma and atopic dermatitis (AD) are common chronic inflammatory diseases that often co-occur, but the underlying shared biological mechanisms remain elusive. In this study, we performed WGCNA analyses on GSE6012 and GSE67472 datasets and identified 24 genes associated with both...

Carbon Dots as Versatile Nanoplatforms for Ophthalmic Therapeutics

Carbon dots (CDs), an emerging class of carbon-based nanomaterials, have attracted increasing interest in ophthalmology owing to their excellent biocompatibility, unique optical properties, tunable surface chemistry, and superior tissue penetration. These features render CDs high...

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

ABSTRACT Idiopathic pediatric uveitis (IPU) is a leading cause of irreversible vision loss in children; however, the genetic and molecular mechanisms underlying this condition remain unclear. Herein, trio‐based whole‐exome sequencing was performed in 28 affected families and targ...

Novel insights of minocycline as a neurovascular protective agent in retinitis pigmentosa

Background/aims Retinitis pigmentosa (RP) is characterised by progressive photoreceptor degeneration accompanied by vascular abnormalities. We have previously demonstrated that minocycline exhibits therapeutic potential in RP. This trial aimed to evaluate its neurovascular protec...

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how t...